性别在青少年特发性关节炎相关性葡萄膜炎中的作用。
The role of gender in juvenile idiopathic arthritis-associated uveitis.
作者信息
Moradi Ahmadreza, Amin Rowayda M, Thorne Jennifer E
机构信息
The Division of Ocular Immunology, Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Woods Building, Room 476, Baltimore, MD, USA.
The Division of Ocular Immunology, Department of Ophthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Woods Building, Room 476, Baltimore, MD, USA ; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
J Ophthalmol. 2014;2014:461078. doi: 10.1155/2014/461078. Epub 2014 Feb 20.
Uveitis is a common complication of juvenile idiopathic arthritis (JIA) affecting up to 30% of patients with JIA. Although the typical bilateral chronic anterior uveitis associated with the persistent and extended oligoarticular and polyarticular, rheumatoid factor negative variants of JIA occurs predominantly in girls, boys may be more commonly affected in the HLA-B27 positive, enthesitis variant of JIA. While female gender has been associated with the development of the chronic anterior uveitis in children with JIA, the clinical course of JIA-associated uveitis may be worse in boys than in girls. The purpose of this paper is to review the available published literature to determine the role of gender in the clinical presentation and outcomes of patients with JIA-associated uveitis.
葡萄膜炎是幼年特发性关节炎（JIA）的常见并发症，影响高达30%的JIA患者。虽然与JIA持续且广泛的少关节型和多关节型、类风湿因子阴性变体相关的典型双侧慢性前葡萄膜炎主要发生在女孩中，但在HLA - B27阳性的JIA附着点炎变体中，男孩可能更常受累。虽然女性性别与JIA患儿慢性前葡萄膜炎的发生有关，但JIA相关葡萄膜炎的临床病程在男孩中可能比女孩更严重。本文的目的是回顾已发表的文献，以确定性别在JIA相关葡萄膜炎患者的临床表现和预后中的作用。
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