经上皮刷检活检 - Oral CDx® - 一种用于早期检测癌前病变和癌性病变的非侵入性方法。
Transepithelial Brush Biopsy - Oral CDx® - A Noninvasive Method for the Early Detection of Precancerous and Cancerous Lesions.
作者信息
S Casparis, J M Borm, M A Tomic, A Burkhardt, M C Locher
机构信息
Faculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland .
Faculty, Institute of Pathology , Reutlingen, Germany .
出版信息
J Clin Diagn Res. 2014 Feb;8(2):222-6. doi: 10.7860/JCDR/2014/7659.4065. Epub 2014 Feb 3.
Abstract
INTRODUCTION
The Oral CDx® brush biopsy (BB) method is a computer-assisted sample analysis that detects abnormal cells in all cell layers of the epithelium of the oral mucosa.
METHOD
We took 263 oral BBs from 200 patients with potentially malignant disorders.
RESULTS
We received 204 negative results and 39 atypical, 7 positive and 13 inadequate results. SBs were taken in 56 cases. Therefore, the sensitivity for the detection of abnormal cells was 90% and the specificity was 44.1%. The positive predictive value accounted for 47.2% and the NPV accounted for 88.2%.
DISCUSSION AND CONCLUSION
For the results of sensitivity and specificity of the Oral CDx® BB, there is still space for improvement but they are already high. Additional methods like DNA-image cytometry may enhance the results. But it is a simple and noninvasive method which does not need a special effort either from the patient or from the clinicians.
摘要
引言
口腔CDx®刷检活检（BB）方法是一种计算机辅助的样本分析方法，可检测口腔黏膜上皮所有细胞层中的异常细胞。
方法
我们从200例潜在恶性疾病患者中采集了263份口腔BB样本。
结果
我们得到204份阴性结果、39份非典型结果、7份阳性结果和13份不充分结果。56例进行了二次活检（SB）。因此，检测异常细胞的敏感性为90%，特异性为44.1%。阳性预测值为47.2%，阴性预测值为88.2%。
讨论与结论
对于口腔CDx®BB的敏感性和特异性结果，仍有改进空间，但已经很高。像DNA图像细胞术等其他方法可能会提高结果。但它是一种简单且非侵入性的方法，患者和临床医生都无需特别费力。
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