血小板衍生生长因子受体信号网络在正常细胞和癌细胞中的作用。

PDGF receptor signaling networks in normal and cancer cells.

机构信息

De Duve Institute, Université catholique de Louvain, Brussels, Belgium.

出版信息

Cytokine Growth Factor Rev. 2014 Jun;25(3):273-83. doi: 10.1016/j.cytogfr.2014.03.003. Epub 2014 Mar 19.

DOI:10.1016/j.cytogfr.2014.03.003

Abstract

For about four decades, platelet-derived growth factors (PDGF) and their receptors have been the subject of intense research, revealing their roles in embryo development and human diseases. Drugs such as imatinib, which selectively inhibit the tyrosine kinase activity of these receptors, have been approved for the treatment of cancers such as gastrointestinal stromal tumors and chronic eosinophilic leukemia. Today, the interest in these factors is still increasing in relationship with new potential clinical applications in cancer, stroke, fibrosis and infectious diseases. This review focuses on the mechanisms of PDGF receptor signaling, with an emphasis on pathways that are important for disease development. Of particular interest, recent studies revealed significant differences between normal and cancer cells regarding signal transduction by these growth factors.

摘要

四十年来，血小板衍生生长因子（PDGF）及其受体一直是研究的热点，揭示了它们在胚胎发育和人类疾病中的作用。伊马替尼等药物选择性抑制这些受体的酪氨酸激酶活性，已被批准用于治疗胃肠道间质瘤和慢性嗜酸性白血病等癌症。如今，由于这些因子在癌症、中风、纤维化和传染病等新的潜在临床应用方面的兴趣仍然在增加。这篇综述重点介绍了 PDGF 受体信号转导的机制，特别强调了对疾病发展很重要的途径。值得注意的是，最近的研究表明，正常细胞和癌细胞在这些生长因子的信号转导方面存在显著差异。