Blaskó K, Schagina L V, Györgyi S, Rontó G
Institute of Biophysics, Semmelweis Medical University, Budapest, Hungary.
Biochimie. 1989 Jan;71(1):99-104. doi: 10.1016/0300-9084(89)90138-7.
Studies for the cation permeability properties of the gramicidin A channel in erythrocyte membranes are presented. It is shown that gramicidin A interacts with the membrane in a cooperative manner, creating aggregates of the antibiotic molecules in the lipid lattice of the membrane. Cationic channels exist in these aggregates with the following order of selectivity: Rb+ greater than Cs+ greater K+ greater than Na+. The cation permeability of the channels depends on the media surrounding the membrane. This finding has been explained on the basis of Hodgkin-Keynes theory for single-file ion diffusion through extra-narrow pores.
本文展示了对红细胞膜中短杆菌肽A通道阳离子渗透特性的研究。结果表明，短杆菌肽A以协同方式与膜相互作用，在膜的脂质晶格中形成抗生素分子聚集体。这些聚集体中存在阳离子通道，其选择性顺序如下：铷离子大于铯离子大于钾离子大于钠离子。通道的阳离子渗透性取决于膜周围的介质。这一发现已根据霍奇金-凯恩斯单排离子通过超窄孔扩散的理论得到解释。
