Neurobiology Department, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.
Baulmon, 34 Jadavpur Central Road, Kolkata 700032, India.
Neurosci Lett. 2014 Jun 6;570:53-7. doi: 10.1016/j.neulet.2014.03.064. Epub 2014 Apr 3.
cAMP response element binding protein (CREB) is a major transcription factor which plays an important role in a wide array of cellular functions. CREB also has a significant function in developing substance abuse. A study was undertaken to identify the single nucleotide polymorphisms (SNP) at selective areas of CREB1 gene in heroin as well as in alcohol addicts in comparison with control population. One hundred and forty control subjects, 112 heroin and 102 alcoholics, all male and residing in Kolkata, a city in eastern India participated in the study. SNPs from several exonic regions of CREB1 gene were assessed to investigate possible associations with addiction. One SNP in exon 3, rs35349697, demonstrated a significant correlation with opioid addiction as well as with alcohol addiction. A novel SNP, also located in exon 3, was identified which showed epistatic interaction with rs35349697 to decrease susceptibility to narcotic addiction in the population. The study is the first report on the identification of a role of CREB1 gene polymorphism with addiction.
环磷酸腺苷反应元件结合蛋白（CREB）是一种主要的转录因子，在广泛的细胞功能中发挥重要作用。CREB 在物质滥用的发展中也具有重要作用。本研究旨在鉴定海洛因成瘾者和酒精成瘾者中 CREB1 基因选择性区域的单核苷酸多态性（SNP），并与对照组进行比较。140 名对照受试者、112 名海洛因成瘾者和 102 名酒精成瘾者均为男性，居住在印度东部城市加尔各答。评估了 CREB1 基因几个外显子区域的 SNPs，以研究与成瘾的可能关联。第 3 外显子中的一个 SNP rs35349697 与阿片类药物成瘾以及酒精成瘾显著相关。还确定了一个新的 SNP，也位于外显子 3 中，与 rs35349697 表现出上位性相互作用，降低了人群中对麻醉成瘾的易感性。该研究首次报道了 CREB1 基因多态性与成瘾的关系。
