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生产针对季节性和潜在大流行性流感病毒的减毒活流感疫苗。

Production of live attenuated influenza vaccines against seasonal and potential pandemic influenza viruses.

机构信息

MedImmune LLC, 319 North Bernardo Avenue, Mountain View, CA 94043, United States.

MedImmune LLC, 319 North Bernardo Avenue, Mountain View, CA 94043, United States.

出版信息

Curr Opin Virol. 2014 Jun;6:34-9. doi: 10.1016/j.coviro.2014.02.008. Epub 2014 Apr 3.

DOI:10.1016/j.coviro.2014.02.008
PMID:24705137
Abstract

Vaccination remains the most effective means to prevent morbidity and mortality caused by influenza epidemics and pandemics. Live attenuated influenza vaccine (LAIV) has been proven to be effective in preventing influenza with broad cross reactivity to drifted strains. Owing to the sophisticated nature of the influenza vaccine production process, the time needed to develop high yield LAIV strains for vaccine production and product release remains a constant challenge. This review summarizes LAIV production process with highlights on the experiences gained during the past decade generating seasonal and pandemic LAIV seeds by reverse genetics strategy.

摘要

接种疫苗仍然是预防流感大流行和流感疫情导致发病和死亡的最有效手段。已证明减毒活流感疫苗（LAIV）可有效预防流感，对漂移株具有广泛的交叉反应性。由于流感疫苗生产过程复杂，因此需要时间开发高产 LAIV 株用于疫苗生产和产品放行，这仍然是一个持续存在的挑战。本综述总结了 LAIV 的生产工艺，重点介绍了过去十年通过反向遗传学策略生成季节性和大流行 LAIV 种子的经验。

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