Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Rehabilitation Center, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, People's Republic of China.
Cancer Lett. 2014 Jul 10;349(1):77-86. doi: 10.1016/j.canlet.2014.03.033. Epub 2014 Apr 3.
To understand lncRNAs expression profiling and their potential functions in bladder cancer, we investigated the lncRNA and coding RNA expression on human bladder cancer and normal bladder tissues. Bioinformatic analysis revealed thousands of significantly differentially expressed lncRNAs and coding mRNA in bladder cancer relative to normal bladder tissue. Co-expression analysis revealed that 50% of lncRNAs and coding RNAs expressed in the same direction. A subset of lncRNAs might be involved in mTOR signaling, p53 signaling, cancer pathways. Our study provides a large scale of co-expression between lncRNA and coding RNAs in bladder cancer cells and lays biological basis for further investigation.
为了了解膀胱癌中 lncRNA 的表达谱及其潜在功能，我们研究了人类膀胱癌和正常膀胱组织中的 lncRNA 和编码 RNA 的表达。生物信息学分析显示，与正常膀胱组织相比，膀胱癌中数千个 lncRNA 和编码 mRNA 的表达存在显著差异。共表达分析显示，50%的 lncRNA 和编码 RNA 表达方向一致。一部分 lncRNA 可能参与 mTOR 信号、p53 信号、癌症途径。我们的研究为膀胱癌细胞中 lncRNA 和编码 RNA 之间的大规模共表达提供了依据，并为进一步研究奠定了生物学基础。
