Fittschen Astrid, Wendlik Inka, Oeztuerk Suemeyra, Kratzer Wolfgang, Akinli Atilla S, Haenle Mark M, Graeter Tilmann
Department of Internal Medicine I, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Abdom Imaging. 2014 Oct;39(5):1009-13. doi: 10.1007/s00261-014-0129-6.
To calculate the prevalence, localization, and growth of sporadic angiomyolipomas and to identify the predominant sex in the largest patient population reviewed to date.
Abdominal ultrasound analyses of 61,389 patients (49.7% women; 50.3% men) were consecutively collected using a PC-based, standardized documentation system from September 1999 to December 2012. The present study evaluates and presents this data.
The population studied includes 270 cases of sporadic angiomyolipoma (184 females; 86 males). This represents an overall prevalence of 0.44%, with 0.60% in the female and 0.28% in the male subpopulations. Mean tumor size was 10.8 ± 5.8 mm. Fifty-seven percent of cases involved the right kidney and 43.0% the left kidney. Only 14 of the 270 patients presented with multiple angiomyolipomas, four of which were bilateral. Sixty-one cases were followed over a mean period of 25 months (range: 1-105 months) and showed no significant increase in tumor size during the period of observation.
The analysis of 61,389 patients revealed a higher prevalence of sporadic angiomyolipoma than previously observed in smaller studies. There was a significantly higher prevalence in females than in males. Multiple and bilateral angiomyolipomas were rare, and tumor growth was marginal.
计算散发性血管平滑肌脂肪瘤的患病率、定位及生长情况，并确定在迄今所研究的最大患者群体中该病的主要患病人群性别。
1999年9月至2012年12月期间，使用基于个人电脑的标准化记录系统，连续收集了61389例患者（49.7%为女性；50.3%为男性）的腹部超声分析数据。本研究对这些数据进行评估并呈现。
所研究的人群包括270例散发性血管平滑肌脂肪瘤患者（184例女性；86例男性）。总体患病率为0.44%，女性亚组患病率为0.60%，男性亚组患病率为0.28%。肿瘤平均大小为10.8±5.8毫米。57%的病例累及右肾，43.0%累及左肾。270例患者中只有14例出现多发性血管平滑肌脂肪瘤，其中4例为双侧性。61例患者接受了平均25个月（范围：1 - 105个月）的随访，在观察期间肿瘤大小无显著增加。
对61389例患者的分析显示，散发性血管平滑肌脂肪瘤的患病率高于此前在较小规模研究中观察到的结果。女性患病率显著高于男性。多发性和双侧性血管平滑肌脂肪瘤较为罕见，肿瘤生长不明显。
