在戒烟治疗结束 12 个月后，伐尼克兰在减轻体重方面比尼古丁贴片更有效：来自日本的一项观察性研究。

Varenicline is more effective in attenuating weight gain than nicotine patch 12 months after the end of smoking cessation therapy: an observational study in Japan.

机构信息

Department of Nursing, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan; Department of Nursing and Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan;

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan;

出版信息

Nicotine Tob Res. 2014 Jul;16(7):1026-9. doi: 10.1093/ntr/ntu045. Epub 2014 Apr 4.

DOI:10.1093/ntr/ntu045

PMID:24706051

Abstract

INTRODUCTION

Although both varenicline and nicotine patch have a beneficial effect in controlling postcessation weight gain, it is not well known whether there is a difference in the effect.

METHODS

We conducted a multi-institutional study on smoking cessation therapy (SCT) administered at 4 Japanese hospitals to compare the body weight change from the first session to 12 months after the end of SCT (at 60 weeks) between varenicline users (n = 307) and nicotine patch users (n = 45).

RESULTS

The mean weight change from baseline to 12 months after the end of SCT was +0.94 kg (SD: 3.59) in varenicline users and +2.78 kg (SD: 4.88) in nicotine patch users (p = .003, by t test). In multivariate linear regression analysis, varenicline users gained significantly less weight than nicotine patch users (coefficient: -1.787, 95% CI = -2.98 to -0.59) with adjustment for success of quit smoking, age, sex, presence of comorbidity, body mass index at baseline, Fagerström Test for Nicotine Dependence, craving at the end of SCT, and nausea through the SCT.

CONCLUSION

Our results indicated that varenicline is more effective in attenuating weight gain than nicotine patch in smokers who received Japanese SCT.

摘要

简介

虽然伐尼克兰和尼古丁贴片都能有效控制戒烟后体重增加，但它们的效果是否存在差异尚不清楚。

方法

我们在日本的 4 家医院进行了一项关于戒烟治疗（SCT）的多机构研究，以比较伐尼克兰使用者（n = 307）和尼古丁贴片使用者（n = 45）在 SCT 结束后第 1 次就诊到 12 个月（60 周）期间体重的变化。

结果

SCT 结束后 12 个月，与基线相比，伐尼克兰使用者的体重平均增加 0.94 公斤（SD：3.59），尼古丁贴片使用者的体重增加 2.78 公斤（SD：4.88）（p =.003，t 检验）。在多变量线性回归分析中，调整戒烟成功率、年龄、性别、合并症、基线时的体重指数、尼古丁依赖 Fagerström 测试、SCT 结束时的渴望程度以及 SCT 期间的恶心程度后，伐尼克兰使用者的体重增加明显少于尼古丁贴片使用者（系数：-1.787，95%CI=-2.98 至-0.59）。