Ma Yan, Zhang Jin-Yu, Wang Chen, Cen Wen, Liu Xin, Feng Wen-Li
Department of Dermatology and Venerology, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Department of Pathology, The Second Clinical Medical College, Shanxi Medical University, Taiyuan, China.
Case Rep Dermatol. 2014 Feb 17;6(1):43-8. doi: 10.1159/000360125. eCollection 2014 Jan.
We describe a case of generalized cutis laxa (CL) in a 7-year-old female child. At 2 months of age, she was found to have a hoarse voice, and at 3 years, she was much smaller than her peers. Her aging face and short stature caught our attention, and the treatment of the patient was accepted by our hospital. She underwent a thorough examination. X-ray of the wrist bone showed a markedly delayed bone age, and thyroid function tests revealed significantly elevated free triiodothyronine 3 and free thyroxine 4 levels, but thyrotropin was within the normal range. Thyroid dysfunction and CL can be associated with lagged growth and development. Whether her abnormal development was due to thyroid dysfunction or CL could not be ascertained. CL is possibly more complex than it has been supposed so far, and is therefore worth to be further studied.
我们描述了一名7岁女童的全身性皮肤松弛症（CL）病例。2个月大时，她被发现声音嘶哑，3岁时，她比同龄人小得多。她衰老的面容和矮小的身材引起了我们的注意，患者被我院收治。她接受了全面检查。腕骨X线显示骨龄明显延迟，甲状腺功能检查显示游离三碘甲状腺原氨酸3和游离甲状腺素4水平显著升高，但促甲状腺激素在正常范围内。甲状腺功能障碍和CL可能与生长发育迟缓有关。她的发育异常是由于甲状腺功能障碍还是CL尚无法确定。CL可能比目前认为的更为复杂，因此值得进一步研究。
