沙特阿拉伯特应性哮喘儿童血清细胞因子水平、白细胞介素 10-1082G/A 和干扰素-γ+874T/A 多态性的相关性。
Association of serum cytokines levels, interleukin 10 -1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia.
机构信息
Medical Laboraotries Department, Faculty of Applied Medical Sciences, Taif University, Saudi Arabia; Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt.
Community Medicine Department, Faculty of Medicine, Taif University, Saudi Arabia.
出版信息
Cell Immunol. 2014 May-Jun;289(1-2):21-6. doi: 10.1016/j.cellimm.2014.03.006. Epub 2014 Mar 24.
The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 -1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p<0.001) higher, while IFN-γ was significantly (p<0.001) lower in patients compared to that of the controls. There was a significant effect of gene polymorphisms of IL-10 (p<0.05) and IFN-γ (p<0.001) in occurrence of atopic asthma and increased IgE level. Polymorphism of IFN-γ gene had an effect on the serum level of IFN-γ. In conclusion, IFN-γ gene polymorphism at position +874 and IL-10 gene polymorphism at position -1082A/G are genetic determinants which contribute to susceptibility to atopic asthma in children from Saudi Arabia.
本研究旨在通过研究血清水平与疾病严重程度之间的关系，阐明白细胞介素-4（IL-4）、白细胞介素-10（IL-10）、白细胞介素-13（IL-13）和干扰素（IFN）-γ水平在特应性哮喘患者中的作用。还研究了 IL-10-1082G/A 和 IFN-γ+874T/A 单核苷酸多态性的作用。该研究纳入了 200 例特应性哮喘儿童和 50 名年龄和性别匹配的健康儿童作为对照组。与对照组相比，患者的 IL-4 和 IL-13 水平显著升高（p<0.001），而 IFN-γ 水平显著降低（p<0.001）。IL-10（p<0.05）和 IFN-γ（p<0.001）基因多态性对特应性哮喘和 IgE 水平升高的发生有显著影响。IFN-γ 基因多态性对 IFN-γ 的血清水平有影响。总之，IFN-γ 基因+874 位和 IL-10 基因-1082A/G 位的多态性是导致沙特阿拉伯儿童特应性哮喘易感性的遗传决定因素。
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