白细胞介素 10 rs1800896 多态性与乳腺癌易感性的关联：一项荟萃分析。

Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.

机构信息

Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.

出版信息

J Int Med Res. 2020 Apr;48(4):300060520904863. doi: 10.1177/0300060520904863.

OBJECTIVE

To evaluate the correlation between interleukin 10 (IL-10) -1082A/G polymorphism (rs1800896) and breast cancers by performing a meta-analysis.

METHODS

The Embase and Medline databases were searched through 1 September 2018 to identify qualified articles. Odds ratios (OR) and corresponding 95% confidence intervals (CIs) were applied to evaluate associations.

RESULTS

In total, 14 case-control studies, including 5320 cases and 5727 controls, were analyzed. We detected significant associations between the -1082 G/G genotype and risk of breast cancer (AA + AG vs. GG: OR = 0.88, 95% CI = 0.80-0.97). Subgroup analyses confirmed a significant association in Caucasian populations (OR = 0.89, 95% CI = 0.80-0.99), in population-based case-control studies (OR = 0.87, 95% CI = 0.78-0.96), and in studies with ≥500 subjects (OR = 0.88, 95% CI = 0.79-0.99) under the recessive model (AA + AG vs. GG). No associations were found in Asian populations.

CONCLUSIONS

The -1082A/G polymorphism is associated with an increased risk of breast cancer. The association between -1082 G/G genotype and increased risk of breast cancer is more significant in Caucasians, in population-based studies, and in larger studies.

目的

通过荟萃分析评估白细胞介素 10（IL-10）-1082A/G 多态性（rs1800896）与乳腺癌之间的相关性。

方法

通过 2018 年 9 月 1 日检索 Embase 和 Medline 数据库，以确定合格的文章。使用比值比（OR）和相应的 95％置信区间（CI）来评估相关性。

结果

共分析了 14 项病例对照研究，包括 5320 例病例和 5727 例对照。我们发现 -1082G/G 基因型与乳腺癌风险之间存在显著相关性（AA+AG 与 GG：OR=0.88，95％CI=0.80-0.97）。亚组分析证实，在白种人群中（OR=0.89，95％CI=0.80-0.99）、基于人群的病例对照研究中（OR=0.87，95％CI=0.78-0.96）和纳入≥500 名患者的研究中（OR=0.88，95％CI=0.79-0.99），这种相关性具有统计学意义，采用的是隐性模型（AA+AG 与 GG）。在亚洲人群中未发现相关性。