School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; Suzhou Polytechnic Institute of Agriculture, Suzhou 215008, PR China.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
Fitoterapia. 2014 Jun;95:220-8. doi: 10.1016/j.fitote.2014.03.028. Epub 2014 Apr 5.
In an effort to identify natural compounds with immunosuppressive activity, nine new flavonoids, including one isoflav-3-ene derivative (1), one coumaronochromone (2), two isoflavanones (3, 4), one isoflavone derivative (6), one isoflavone (7), three flavonols (8, 9, 10), as well as one known compound, hydroisoflavone C (5), were isolated from the roots of Campylotropis hirtella. The structures of these compounds were elucidated by extensive spectroscopic measurements. All of the compounds were assessed for immunosuppressive activity. Among the isolates, compound 2 showed good inhibitory activity against mitogen-induced splenocyte proliferation with an IC50 of 0.28 μM and relatively low cytotoxicity.
为了寻找具有免疫抑制活性的天然化合物，从山黧豆的根部分离得到了 9 个新的黄酮类化合物，包括一个异黄酮-3-烯衍生物（1）、一个香豆素色酮（2）、两个异戊烯黄酮（3、4）、一个异黄酮衍生物（6）、一个异黄酮（7）、三个黄酮醇（8、9、10）以及一个已知化合物氢化异黄酮 C（5）。通过广泛的光谱测量确定了这些化合物的结构。所有化合物均进行了免疫抑制活性评估。在分离得到的化合物中，化合物 2 对有丝分裂原诱导的脾细胞增殖具有良好的抑制活性，IC50 为 0.28 μM，且细胞毒性相对较低。
