Liu Zheng, Ao Deng, Yang Huixia, Wang Yan
Department of Child, Adolescent and Women's Health, School of Public Health, Peking University, Beijing 100191, China.
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China. Email:
Chin Med J (Engl). 2014;127(7):1255-60.
Gestational diabetes mellitus (GDM) is a common complication during pregnancy, and gestational weight gain is one of the major and modifiable risk factors. This study aims to estimate the relationship between the rate of gestational weight gain before diagnosis of GDM and the subsequent risk of GDM.
A case-control study was conducted with 90 GDM cases and 165 women in the control group from May 2012 to August 2012 at Peking University First Affiliated Hospital. GDM was diagnosed according to the standards issued by the Ministry of Health of China in 2011. The plasma glucose levels, weights, and covariate data of the women were obtained based on medical records. Univariate analysis and unconditional Logistic regression model were used to estimate the associations.
After adjusting for age at delivery, parity, and pre-pregnancy body mass index, the risk of GDM increased with increasing rates of gestational weight gain. Compared with the lower rate of gestational weight gain (less than 0.28 kg per week), a rate of weight gain of 0.28 kg per week or more was associated with increased risk of GDM (odds ratio: 2.03; 95% confidence interval: 1.15 to 3.59). The association between the rate of gestational weight gain and GDM was primarily attributed to the increased weight gain in the first trimester.
High rates of gestational weight gain, particular during early pregnancy, may increase a woman's risk of GDM.
妊娠期糖尿病（GDM）是孕期常见的并发症，孕期体重增加是主要的可改变风险因素之一。本研究旨在评估GDM诊断前的孕期体重增加率与后续发生GDM风险之间的关系。
2012年5月至2012年8月，在北京大学第一医院进行了一项病例对照研究，其中90例为GDM病例，165名女性作为对照组。GDM根据中国卫生部2011年发布的标准进行诊断。根据病历获取这些女性的血糖水平、体重和协变量数据。采用单因素分析和非条件Logistic回归模型评估相关性。
在调整分娩年龄、产次和孕前体重指数后，GDM风险随着孕期体重增加率的升高而增加。与较低的孕期体重增加率（每周低于0.28千克）相比，每周体重增加0.28千克或更多与GDM风险增加相关（比值比：2.03；95%置信区间：1.15至3.59）。孕期体重增加率与GDM之间的关联主要归因于孕早期体重增加较多。
孕期体重增加率高，尤其是在孕早期，可能会增加女性患GDM的风险。
