Faculty of Medicine, Department of Biostatistics and Medical Informatics, Karadeniz Technical University, Trabzon, Turkey.
Faculty of Medicine, Department of Gynecology and Obstetrics, Recep Tayyip Erdoğan University, Rize, Turkey.
Med Biol Eng Comput. 2023 Jul;61(7):1649-1660. doi: 10.1007/s11517-023-02800-7. Epub 2023 Feb 27.
The study aimed to develop a clinical diagnosis system to identify patients in the GD risk group and reduce unnecessary oral glucose tolerance test (OGTT) applications for pregnant women who are not in the GD risk group using deep learning algorithms. With this aim, a prospective study was designed and the data was taken from 489 patients between the years 2019 and 2021, and informed consent was obtained. The clinical decision support system for the diagnosis of GD was developed using the generated dataset with deep learning algorithms and Bayesian optimization. As a result, a novel successful decision support model was developed using RNN-LSTM with Bayesian optimization that gave 95% sensitivity and 99% specificity on the dataset for the diagnosis of patients in the GD risk group by obtaining 98% AUC (95% CI (0.95-1.00) and p < 0.001). Thus, with the clinical diagnosis system developed to assist physicians, it is planned to save both cost and time, and reduce possible adverse effects by preventing unnecessary OGTT for patients who are not in the GD risk group.
本研究旨在开发一种临床诊断系统,利用深度学习算法识别 GD 风险组患者,并减少非 GD 风险组孕妇不必要的口服葡萄糖耐量试验(OGTT)应用。为此,进行了一项前瞻性研究,数据取自 2019 年至 2021 年的 489 名患者,并获得了知情同意。使用生成的数据集和深度学习算法以及贝叶斯优化,开发了用于 GD 诊断的临床决策支持系统。结果,使用 RNN-LSTM 和贝叶斯优化开发了一种新的成功决策支持模型,该模型在数据集上的诊断 GD 风险组患者的灵敏度为 95%,特异性为 99%,AUC 为 98%(95%CI(0.95-1.00),p<0.001)。因此,通过为非 GD 风险组患者开发临床诊断系统,计划节省成本和时间,并通过预防不必要的 OGTT 减少可能的不良反应。