Department of Electrical and Computer Engineering, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Cells. 2013 May 31;2(2):393-413. doi: 10.3390/cells2020393.
One of the principle tasks of systems biology has been the reverse engineering of signaling networks. Because of the striking similarities to engineering systems, a number of analysis and design tools from engineering disciplines have been used in this process. This review looks at several examples including the analysis of homeostasis using control theory, the attenuation of noise using signal processing, statistical inference and the use of information theory to understand both binary decision systems and the response of eukaryotic chemotactic cells.
系统生物学的主要任务之一是对信号网络进行反向工程。由于与工程系统惊人的相似，工程学科中的许多分析和设计工具已被用于这个过程。本文回顾了几个例子，包括使用控制理论分析内稳态、使用信号处理衰减噪声、统计推断以及使用信息论来理解二进制决策系统和真核趋化细胞的反应。
