Institute for Biomedical Research "Alberto Sols", CSIC-UAM, C/ Arturo Duperier 4, Madrid 28029, Spain.
Departamentos de Anatomía y Biología Celular, Universidad de Cantabria, Santander 39011, Spain.
Cells. 2012 Aug 2;1(3):428-48. doi: 10.3390/cells1030428.
Autophagy is an evolutionarily conserved catabolic process by which cells degrade their own components through the lysosomal machinery. In physiological conditions, the mechanism is tightly regulated and contributes to maintain a balance between synthesis and degradation in cells undergoing intense metabolic activities. Autophagy is associated with major tissue remodeling processes occurring through the embryonic, fetal and early postnatal periods of vertebrates. Here we survey current information implicating autophagy in cellular death, proliferation or differentiation in developing vertebrates. In developing systems, activation of the autophagic machinery could promote different outcomes depending on the cellular context. Autophagy is thus an extraordinary tool for the developing organs and tissues.
自噬是一种进化上保守的分解代谢过程，通过溶酶体机制，细胞降解自身成分。在生理条件下，该机制受到严格调控，有助于在代谢活跃的细胞中维持合成与降解之间的平衡。自噬与脊椎动物胚胎、胎儿和出生后早期的主要组织重塑过程有关。在这里，我们调查了自噬在发育中的脊椎动物细胞死亡、增殖或分化中所涉及的最新信息。在发育系统中，自噬机制的激活可能会根据细胞环境而产生不同的结果。因此，自噬是发育中器官和组织的一个非凡工具。
