Han Shufen, Zhang Hong, Chi Jing, Liu Yaqi, Zhou Siyu, Zhai Chengkai
Department of Nutrition and Food Hygiene, Public Health School, Medical College of Soochow University, Suzhou 215123, China.
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Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Jan;48(1):23-7.
To evaluate the effects of compound whole grain-soybean on insulin resistance and serum adipocytokines levels in impared fasting glucose population.
According to inclusion and exclusion criteria, 163 cases of impared fasting glucose (IFG) Chinese Han population from the age of 40 to 75 years old, were screened from 12 community health centers of three main districts of Nanjing city by the multi-stage cluster and simple randomization method from March to September, 2008. The IFG subjects were randomly divided into the intervention group (87 individuals) and control group (76 individuals) by quasi-experimental design. The intervention group was provided with compound whole grain-soybean and health education, while only health education was provided for the control group. Body mass index (BMI), waist-to-hip ratio (WHR), lipid profiles, fasting blood glucose (FBG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR), adipocytokines including leptin, lipocalin 2 (LCN-2) and adiponectin (ADP) levels were measured before and after the half a year intervention period. Chi square test was used to analyze the distribution differences. Two-sample t-test was used to compare the differences of the two groups before and after the half a year intervention period, and paired t-test was used to compare the differences between before and after intervention in the intervention group or control group. Wilcoxon rank sum test was used to compare the differences of all indexes between after and before dietary intervention.
After dietary intervention for half a year on the IFG population, BMI ((24.87 ± 3.69) kg/m(2)), FBG((6.27 ± 0.24) mmol/L), FINS((7.14 ± 1.05) mU/L) , HOMA-IR (1.99 ± 0.31), leptin ((13.07 ± 2.22) µg /L), LCN-2 ((67.42 ± 18.20) µg/L) of intervention group were decreased significantly compared to the levels of BMI ((25.16 ± 4.07) kg/m(2)), FBG((6.40 ± 0.28) mmol/L), FINS ((7.32 ± 1.54) mU/L), HOMA-IR (2.08 ± 0.45), leptin ((13.43 ± 2.52) µg/L), LCN-2((74.87 ± 17.81) µg/L) before dietary intervention, t values were 4.48, 7.08, 2.05, 3.39, 3.28 and 6.36, respectively, and all P values were < 0.05, while ADP ((5.07 ± 1.51) mg/L) of intervention group after dietary intervention was increased significantly compared to the level of ADP ((4.92 ± 1.53) mg/L) before dietary intervention, t = -2.47 and P < 0.05. The medians (P25, P 75) of differences after and before dietary intervention in the intervention group were BMI (-0.25(-0.68, 0.02) kg/m(2)), FBG (-0.08 (-0.20, 0.00) mmol/L), FINS (-0.15(-0.32, 0.00) mU/L), HOMA-IR (-0.07(-0.12, -0.03)), leptin (-0.36(-0.77, 0.12) µg/L), LCN-2 (-5.85(-14.29, -0.71) µg/L) and ADP (0.15(-0.13, 0.36) mg/L), and the medians of differences of after and before dietary intervention in the control group were BMI (0.00(-0.23, 0.29) kg/m(2)), FBG (0.00(-0.03, 0.04) mmol/L), FINS (-0.01(-0.13, 0.04) mU/L), HOMA-IR (-0.01(-0.05, 0.02)), leptin (-0.07 (-0.57, 0.46) µg/L), LCN-2 (-0.85(-5.39, 1.63) µg/L) and ADP (0.02(-0.19, 0.13) mg/L). There were significantly statistical differences between them (Z values were -3.65, -4.88, -3.08, -5.23, -2.16, -4.43 and 3.05, all P values were <0.05).
Dietary intervention of compound whole grain-soybean can improves glucose level, increase insulin sensitivity and ameliorate insulin resistance state of IFG population.
评估复合全谷物 - 大豆对空腹血糖受损人群胰岛素抵抗及血清脂肪细胞因子水平的影响。
按照纳入与排除标准，于2008年3月至9月采用多阶段整群及简单随机化方法，从南京市三个主要城区的12个社区卫生服务中心筛查出163例年龄在40至75岁的中国汉族空腹血糖受损（IFG）人群。通过准实验设计将IFG受试者随机分为干预组（87人）和对照组（76人）。干预组给予复合全谷物 - 大豆及健康教育，对照组仅给予健康教育。在半年干预期前后测量体重指数（BMI）、腰臀比（WHR）、血脂谱、空腹血糖（FBG）、空腹胰岛素（FINS）及胰岛素抵抗稳态模型评估（HOMA - IR），以及包括瘦素、脂质运载蛋白2（LCN - 2）和脂联素（ADP）在内的脂肪细胞因子水平。采用卡方检验分析分布差异。采用两样本t检验比较两组在半年干预期前后的差异，采用配对t检验比较干预组或对照组干预前后的差异。采用Wilcoxon秩和检验比较饮食干预前后所有指标的差异。
对IFG人群进行半年饮食干预后，干预组的BMI（（24.87 ± 3.69）kg/m²）、FBG（（6.27 ± 0.24）mmol/L）、FINS（（7.14 ± 1.05）mU/L）、HOMA - IR（1.99 ± 0.31）、瘦素（（13.07 ± 2.22）μg/L）、LCN - 2（（67.42 ± 18.20）μg/L）较饮食干预前的BMI（（25.16 ± 4.07）kg/m²）、FBG（（6.40 ± 0.28）mmol/L）、FINS（（7.32 ± 1.54）mU/L）、HOMA - IR（2.08 ± 0.45）、瘦素（（13.43 ± 2.52）μg/L）、LCN - 2（（74.87 ± 17.81）μg/L）显著降低，t值分别为4.48、7.08、2.05、3.39、3.28和6.36，所有P值均<0.05，而干预组饮食干预后的ADP（（5.07 ± 1.51）mg/L）较饮食干预前的ADP（（4.92 ± 1.53）mg/L）显著升高，t = -2.47，P < 0.05。干预组饮食干预前后差异的中位数（P25，P75）为BMI（-0.25（-0.68，0.02）kg/m²）、FBG（-0.08（-0.20，0.00）mmol/L）、FINS（-0.15（-0.32，0.00）mU/L）、HOMA - IR（-0.07（-0.12，-0.03））、瘦素（-0.36（-0.77，0.12）μg/L）、LCN - 2（-5.85（-14.29，-0.71）μg/L）和ADP（0.15（-0.13，0.36）mg/L），对照组饮食干预前后差异的中位数为BMI（0.00（-0.23，0.29）kg/m²）、FBG（0.00（-0.03，0.04）mmol/L）、FINS（-0.01（-0.13，0.04）mU/L）、HOMA - IR（-0.01（-0.05，0.02））、瘦素（-0.07（-0.57，0.46）μg/L）、LCN - 2（-0.85（-5.39，1.63）μg/L）和ADP（0.02（-0.19，0.13）mg/L）。它们之间存在显著统计学差异（Z值分别为 -3.65、-4.88、-3.08、-5.23、-2.16、-4.43和3.05，所有P值均<0.05）。
复合全谷物 - 大豆饮食干预可改善IFG人群的血糖水平，提高胰岛素敏感性，改善胰岛素抵抗状态。
