Chi Jing, Zhang Qun, Zhai Cheng-Kai, Zhang Hong, Han Shu-Fen, Liu Ya-Qi, Zhou Si-Yu
Department of Nutrition and Food Hygiene, Public Health School, Southeast University, Nanjing 210009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Feb;46(2):143-7.
To explore the influence of compound whole grain complex antioxidant chain on oxidative stress to the hyperlipidemia population.
From March 2008 to March 2009, 418 hyperlipemia residents (45 to 75 years of age) of Han group were screened from 3 main districts in Nanjing, according to the community, blood lipids and oxidative indicators, stratified into intervention and control group by quasi-experimental design. The intervention group (212 individuals) were provided with compound whole grain and health education while only health education was provided for the control group (206 individuals). Body mass index (BMI), waist-to-hip ratio (WHR), total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) and oxidative indicators (including T-AOC, MDA, SOD, GSH-Px) were measured before and after the one-year intervention period. Analyses of the correlation between posture, biochemical markers and oxidative stress indicators before and after intervention were carried out.
After intervention, BMI ((25.53 ± 2.77) kg/m(2)), WHR (0.82 ± 0.03), TC ((4.60 ± 0.98) mmol/L), TG ((1.26 ± 0.88) mmol/L) in the intervention group were decreased significantly compared to the levels of BMI ((26.60 ± 3.18) kg/m(2)), WHR (0.93 ± 0.05), TC ((4.97 ± 1.02) mmol/L), TG ((1.98 ± 1.11) mmol/L) in the control group (all P values < 0.05); while HDL-C ((1.34 ± 0.26) mmol/L) in the intervention group was increased significantly compared to the level of HDL-C ((1.18 ± 0.17) mmol/L) in the control group (P < 0.05); After intervention, levels of T-AOC (19.52 ± 0.81), SOD ((85.42 ± 21.65) U/ml) and GSH-Px ((128.26 ± 33.65) µmol/L) were increased significantly compared to the levels of T-AOC (11.11 ± 1.30), SOD ((78.68 ± 30.48) U/ml) and GSH-Px ((118.48 ± 24.19) µmol/L) in the control group (all P values < 0.05); while MDA ((1.78 ± 1.16) nmol/ml) decreased significantly compared to the level of MDA ((2.12 ± 1.37) nmol/ml in the control group (P < 0.05); Pearson product moment correlation analysis showed that: T-AOC with TC, TG, BMI showed a negative correlation (r values were -0.258, -0.266, -0.230, respectively, all P values < 0.05), while with HDL-C was a positive correlation (r values was 0.194, P < 0.05); SOD with TC, TG, BMI showed a negative correlation (r values were -0.282, -0.311, -0.217, respectively, all P values < 0.05), while with HDL-C was a positive correlation (r values was 0.169, P < 0.05).
Compound whole grain could improve lipid metabolism to the hyperlipidemia population. There was a correlation between common human metabolism and the levels of oxidative stress.
探讨复合全谷物复合抗氧化链对高脂血症人群氧化应激的影响。
2008年3月至2009年3月，从南京3个主要城区筛选出418名汉族高脂血症居民（年龄45至75岁），根据社区、血脂和氧化指标，采用准实验设计将其分为干预组和对照组。干预组（212人）给予复合全谷物并进行健康教育，对照组（206人）仅给予健康教育。在为期一年的干预期前后，测量体重指数（BMI）、腰臀比（WHR）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）以及氧化指标（包括总抗氧化能力（T-AOC）、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px））。对干预前后的体态、生化指标和氧化应激指标之间的相关性进行分析。
干预后，干预组的BMI（（25.53±2.77）kg/m²）、WHR（0.82±0.03）、TC（（4.60±0.98）mmol/L）、TG（（1.26±0.88）mmol/L）与对照组的BMI（（26.60±3.18）kg/m²）、WHR（0.93±0.05）、TC（（4.97±1.02）mmol/L）、TG（（1.98±1.11）mmol/L）相比均显著降低（所有P值<0.05）；而干预组的HDL-C（（1.34±0.26）mmol/L）与对照组的HDL-C（（1.18±0.17）mmol/L）相比显著升高（P<0.05）；干预后，T-AOC（19.52±0.81）、SOD（（85.�2±21.65）U/ml）和GSH-Px（（128.26±33.65）µmol/L）水平与对照组的T-AOC（11.11±1.30）、SOD（（78.68±30.48）U/ml）和GSH-Px（（118.48±24.19）µmol/L）相比均显著升高（所有P值<0.05）；而MDA（（1.78±1.16）nmol/ml）与对照组的MDA（（2.12±1.37）nmol/ml）相比显著降低（P<0.05）；Pearson积矩相关分析表明：T-AOC与TC、TG、BMI呈负相关（r值分别为-0.258、-0.266、-0.230，所有P值<0.05），而与HDL-C呈正相关（r值为0.194，P<><0.05）；SOD与TC、TG、BMI呈负相关（r值分别为-0.282、-0.311、-0.217，所有P值<0.05），而与HDL-C呈正相关（r值为0.169，P<><0.05）。
复合全谷物可改善高脂血症人群的脂质代谢。人体常见代谢与氧化应激水平之间存在相关性。
