Zhang Qun, Zhai Cheng-Kai, Wang Yan-Li, Guo Yan-Bo, Ding Zhou-Bo, Jin Xin
Department of Nutrition and Food Hygiene, Public Health School, Southeast University, Nanjing 210009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2010 Jan;44(1):39-43.
To find out the effects of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) genetic polymorphism and nutrition intervention to blood lipid abnormal population.
412 hyperlipemia residents of Han group were screened from 3 main districts in Nanjing by multistage stratified cluster random sampling, and separated into nutritional intervention and control group by simple random method. The intervention group (221 individuals) were provided with coarse good grain and health education while only health education was provided for the control group (191 individuals). Medical examinations (including body mass index (BMI), waist-to-hip ratio (WHR); total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and fasting blood glucose (FBG)) were taken every 6 months between March 2007 and March 2008, and PPARgamma2 genetic polymorphism was also detected later.
After intervention, TC levels of intervention group and control group were (4.90 +/- 0.86) and (5.16 +/- 0.94) mmol/L respectively; TG levels were (1.68 +/- 0.97) and (2.29 +/- 1.10) mmol/L respectively; HDL-C levels were (1.35 +/- 0.36) and (1.16 +/- 0.33) mmol/L respectively, all of the differences were significant in statistics (t values were -2.95, -6.01, 5.55 respectively, P < 0.01). The levels of BMI ((24.81 +/- 3.21) kg/m(2)), WHR (0.88 +/- 0.07), FBG ((5.40 +/- 1.17) mmol/L), TC ((4.92 +/- 0.87) mmol/L) and TG ((1.68 +/- 1.01) mmol/L) decreased significantly (t values were 19.06, 16.43, 1.98, 8.86, -14.32 respectively, P < 0.01) compared to the levels before intervention (BMI (25.39 +/- 3.30) kg/m(2), WHR (0.92 +/- 0.07), FBG (6.07 +/- 2.17) mmol/L, TC (5.28 +/- 0.94) mmol/L and TG (2.70 +/- 1.86) mmol/L), while HDL-C (1.37 +/- 0.36) mmol/L increased significantly compared to the level before intervention (1.13 +/- 0.42) mmol/L (t = -7.68, P < 0.01) in the individuals with Pro/Pro of intervention group. WHR (0.90 +/- 0.06) and TG ((1.71 +/- 0.59) mmol/L) decreased significantly compared to the levels before intervention (WHR (0.95 +/- 0.06) and TG (2.58 +/- 1.12) mmol/L) (t values were -3.53 and -8.05 respectively, P < 0.01) in the ones with Pro/Ala. Moreover, susceptibility of change for BMI in Pro/Pro genotype carriers ((-1.21 +/- 1.02) kg/m(2)) was significantly greater than that in Pro/Ala genotype carriers ((-0.58 +/- 1.85) kg/m(2), t = -6.29, P < 0.01).
Several indices of individuals with Pro/Pro improved obviously after nutrition intervention, which showed that effects of intervention to these people were better than those with Pro/Ala and Ala/Ala.
探讨过氧化物酶体增殖物激活受体γ2（PPARγ2）基因多态性及营养干预对血脂异常人群的影响。
采用多阶段分层整群随机抽样方法，从南京市3个主要城区筛选出412例汉族高脂血症居民，采用简单随机方法将其分为营养干预组和对照组。干预组（221例）给予粗粮及健康教育，对照组（191例）仅给予健康教育。在2007年3月至2008年3月期间，每6个月进行一次医学检查（包括体重指数（BMI）、腰臀比（WHR）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和空腹血糖（FBG）），之后还检测了PPARγ2基因多态性。
干预后，干预组和对照组的TC水平分别为（4.90±0.86）和（5.16±0.94）mmol/L；TG水平分别为（1.68±0.97）和（2.29±1.10）mmol/L；HDL-C水平分别为（1.35±0.36）和（(1.16±0.33）mmol/L，所有差异均有统计学意义（t值分别为-2.95、-6.01、5.55，P<0.01）。干预组中Pro/Pro个体干预后的BMI（(24.81±3.21）kg/m²）、WHR（0.88±0.07）、FBG（(5.40±1.17）mmol/L）、TC（(4.92±0.87）mmol/L）和TG（(1.68±1.01）mmol/L）较干预前（BMI（25.39±3.30）kg/m²、WHR（0.92±0.07）、FBG（6.07±2.17）mmol/L、TC（5.28±0.94）mmol/L和TG（2.70±1.86）mmol/L）显著降低（t值分别为19.06、16.43、1.98、8.86、-14.32，P<0.01），而HDL-C（(1.37±0.36）mmol/L）较干预前（1.13±0.42）mmol/L显著升高（t=-7.68，P<0.01）。干预组中Pro/Ala个体干预后的WHR（0.90±0.06）和TG（(1.71±0.59）mmol/L）较干预前（WHR（0.95±0.06）和TG（2.58±1.12）mmol/L）显著降低（t值分别为-3.53和-8.05，P<0.01）。此外，Pro/Pro基因型携带者BMI的变化易感性（(-1.21±1.02）kg/m²）显著大于Pro/Ala基因型携带者（(-0.58±1.85）kg/m²，t=-6.29，P<0.01）。
营养干预后，Pro/Pro个体的多项指标改善明显，表明干预对这些人的效果优于Pro/Ala和Ala/Ala个体。
