Feng Y-Q, Li Y U, Xiao W-D, Wang G-X, Li Y O
Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
Department of Urologic Surgery, Jiangxi Institute of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
Genet Mol Res. 2015 Oct 28;14(4):13391-402. doi: 10.4238/2015.October.28.1.
The aim of this study was to investigate the association between the cyclooxygenase 2 (COX2) -765G>C (rs20417) polymorphism and prostate cancer (PC) risk using meta-analysis. A systematic literature search was performed using the PubMed, Embase, Cochrane Library, and Google Scholar databases by using the terms "cyclooxygenase-2/COX-2/PTGs2", "polymorphism" or "variation", and "prostate" and "cancer" or "carcinoma" to identify relevant articles up to June 14, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for PC risk associated with COX2 -765G>C polymorphism using fixed- and random-effect models. We identified a total of nine publications, including 5952 cases and 5078 controls, to investigate the effect of COX2 -765G>C on PC risk, and found no significant association in any genetic model tested (CC vs GG: OR = 0.993, 95%CI = 0.923-1.068; GC+CC vs GG: OR = 1.041, 95%CI = 0.931-1.103; CC vs GC+GG: OR = 0.858, 95%CI = 0.689-1.067; CC vs GG: OR = 0.871, 95%CI = 0.689-1.086; GC vs GG: OR = 1.032, 95%CI = 0.945-1.127). Power analysis and tests for publication bias ensured the reliability of our results. This meta-analysis suggested that the functional COX2 -765G>C polymorphism, located in the COX2 gene promoter, is unlikely to be associated with PC risk. However, additional larger, well-designed studies are still required to reach a conclusive result on this issue.
本研究旨在通过荟萃分析探究环氧化酶2（COX2）-765G>C（rs20417）基因多态性与前列腺癌（PC）风险之间的关联。通过使用“环氧化酶-2/COX-2/PTGs2”、“多态性”或“变异”以及“前列腺”和“癌”或“腺癌”等术语，对PubMed、Embase、Cochrane图书馆和谷歌学术数据库进行系统文献检索，以识别截至2014年6月14日的相关文章。使用固定效应模型和随机效应模型评估与COX2 -765G>C基因多态性相关的PC风险的粗比值比（OR）及95%置信区间（CI）。我们共鉴定出9篇出版物，包括5952例病例和5078例对照，以研究COX2 -765G>C对PC风险的影响，发现在任何测试的遗传模型中均无显著关联（CC与GG：OR = 0.993，95%CI = 0.923 - 1.068；GC + CC与GG：OR = 1.041，95%CI = 0.931 - 1.103；CC与GC + GG：OR = 0.858，95%CI = 0.689 - 1.067；CC与GG：OR = 0.871，95%CI = 0.689 - 1.086；GC与GG：OR = 1.032，95%CI = 0.945 - 1.127）。功效分析和发表偏倚检验确保了我们结果的可靠性。该荟萃分析表明，位于COX2基因启动子区的功能性COX2 -765G>C基因多态性不太可能与PC风险相关。然而，仍需要更多更大规模、设计良好的研究才能就该问题得出确凿结论。
