Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center and the Technion, Haifa, Israel.
Int Arch Allergy Immunol. 2014;163(4):245-51. doi: 10.1159/000360477. Epub 2014 Apr 2.
When the pathogenesis of allergic inflammatory diseases such as asthma, allergic rhinitis and atopic dermatitis is discussed, one should take into consideration the involvement of regulatory cells/molecules whose role is to prevent the induction and/or deterioration of such diseases. The involvement of T regulatory cells and FoxPp3 is well established in asthma, but only little is known about the involvement of B regulatory cells (Bregs) and the soluble regulatory molecule semaphorin3A (sema3A) in atopic diseases. During the last decade, research has sought to better define the various subtypes of Breg cells and how similar they are to their parallel subtypes of Tregs. In this review, we focus on the newly reported role of Bregs in both experimental and human models of asthma. Bregs are also involved in the pathophysiology of food allergy. We also show how sema3A plays a role in the pathogenesis of allergic rhinitis and atopic dermatitis. Determining the above processes could facilitate the use of regulatory molecules as therapeutic tools in treating these diseases.
当讨论哮喘、过敏性鼻炎和特应性皮炎等过敏性炎症性疾病的发病机制时，应考虑到调节性细胞/分子的参与，其作用是预防这些疾病的诱导和/或恶化。T 调节细胞和 FoxPp3 在哮喘中的作用已得到充分证实，但关于 B 调节细胞（Bregs）和可溶性调节分子信号素 3A（sema3A）在特应性疾病中的作用知之甚少。在过去的十年中，研究旨在更好地定义 Breg 细胞的各种亚型，以及它们与平行的 Treg 亚型有多么相似。在这篇综述中，我们重点介绍了 Bregs 在哮喘的实验和人类模型中的新报告作用。Bregs 也参与了食物过敏的病理生理学。我们还展示了 sema3A 如何在过敏性鼻炎和特应性皮炎的发病机制中发挥作用。确定上述过程可以促进将调节分子用作治疗这些疾病的治疗工具。
