信号素3A：免疫介导疾病中的一种潜在治疗工具。
Semaphorin3A: A potential therapeutic tool in immune-mediated diseases.
作者信息
Vadasz Zahava, Toubi Elias
机构信息
Department of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Haifa, Israel.
出版信息
Eur J Rheumatol. 2018 Mar;5(1):58-61. doi: 10.5152/eurjrheum.2017.17076. Epub 2017 Dec 7.
Abstract
The significance of semaphorin3A (sema3A) in regulating immune-mediated inflammation is widely reported. There are multiple mechanisms involved in the process of sema3A-mediated regulation. One of them is the ability of sema3A to maintain a sufficient regulation of both T-cell and B-cell activation. Because it is involved in the pathogenesis of many autoimmune, infectious, and malignant diseases, sema3A turns to be a promising therapeutic tool to be studied and applied in these diseases.
摘要
信号素3A（sema3A）在调节免疫介导的炎症中的重要性已被广泛报道。sema3A介导的调节过程涉及多种机制。其中之一是sema3A对T细胞和B细胞激活均具有充分调节的能力。由于sema3A参与了许多自身免疫性、感染性和恶性疾病的发病机制，它成为一种有前景的治疗工具，有待在这些疾病中进行研究和应用。
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