Sá Emmanuela Quental Callou de, Sá Francisco Carleial Feijó de, Oliveira Kelly Cristina, Feres Fausto, Verreschi Ieda Therezinha Nascimento
Universidade Federal do Ceará, Barbalha, Ceará, Brazil.
Universidade Federal de São Paulo, São Paulo, Brazil.
Sao Paulo Med J. 2014;132(2):111-5. doi: 10.1590/1516-3180.2014.1322666.
Metabolic syndrome consists of a set of factors that imply increased risk of cardiovascular diseases. The objective here was to evaluate the association between sex hormone-binding globulin (SHBG), sex hormones and metabolic syndrome among men.
Retrospective analysis on data from the study "Endogenous oestradiol but not testosterone is related to coronary artery disease in men", conducted in a hospital in São Paulo.
Men (aged 40-70) who underwent coronary angiography were selected. The age, weight, height, waist circumference, body mass index and prevalence of dyslipidemia, hypertension and diabetes of each patient were registered. Metabolic syndrome was defined in accordance with the criteria of the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (NCEP-ATPIII). Serum samples were collected to assess the levels of glucose, total cholesterol, HDL-cholesterol (high density lipoprotein), triglycerides, albumin, SHBG, estradiol and total testosterone (TT). The levels of LDL-cholesterol (low density lipoprotein) were calculated using Friedewald's formula and free testosterone (FT) and bioavailable testosterone (BT) using Vermeulen's formula.
141 patients were enrolled in the study. The prevalence of metabolic syndrome was significantly higher in the first SHBG tercile than in the second and third terciles. A statistically significant positive association between the SHBG and TT values was observed, but no such association was seen between SHBG, BT and FT.
Low serum levels of SHBG are associated with higher prevalence of metabolic syndrome among male patients, but further studies are required to confirm this association.
代谢综合征由一系列因素组成，这些因素意味着心血管疾病风险增加。本文的目的是评估男性性激素结合球蛋白（SHBG）、性激素与代谢综合征之间的关联。
对在圣保罗一家医院进行的“内源性雌二醇而非睾酮与男性冠状动脉疾病相关”研究的数据进行回顾性分析。
选取接受冠状动脉造影的40至70岁男性。记录每位患者的年龄、体重、身高、腰围、体重指数以及血脂异常、高血压和糖尿病的患病率。根据美国国家胆固醇教育计划成人高胆固醇检测、评估和治疗专家小组第三次报告（NCEP-ATPIII）的标准定义代谢综合征。采集血清样本以评估血糖、总胆固醇、高密度脂蛋白胆固醇（HDL-胆固醇）、甘油三酯、白蛋白、SHBG、雌二醇和总睾酮（TT）的水平。使用Friedewald公式计算低密度脂蛋白胆固醇（LDL-胆固醇）水平，使用Vermeulen公式计算游离睾酮（FT）和生物可利用睾酮（BT）水平。
141名患者纳入研究。代谢综合征的患病率在SHBG三分位数的第一组中显著高于第二组和第三组。观察到SHBG与TT值之间存在统计学显著的正相关，但SHBG、BT与FT之间未观察到此类关联。
男性患者血清SHBG水平低与代谢综合征的较高患病率相关，但需要进一步研究来证实这种关联。
