Jarecki Piotr, Herman Waldemar A, Pawliczak Elżbieta, Lacka Katarzyna
Student Scientific Club of Endocrinology, Poznan University of Medical Sciences, Poznań, Wielkopolskie, Poland.
Outpatients Clinic of Endocrine Diseases, Wschowa, Lubuskie, Poland.
Diabetes Metab Syndr Obes. 2019 Oct 21;12:2181-2191. doi: 10.2147/DMSO.S218545. eCollection 2019.
In men suffering from metabolic syndrome, accompanying insulin resistance may result in a lowering of sex hormone-binding globulin (SHBG) plasma levels and cause changes in their androgenic status.
The objective of the research was to assess selected androgens and SHBG plasma levels in males meeting diagnostic criteria for MS compared to healthy males.
The group consisted of 65 men aged between 40 and 70 years old fitting IDF metabolic syndrome criteria and 84 controls. Dehydroepiandrosterone (DHEA) and its sulphate (DHEA-S), total and free testosterone and SHBG serum levels were evaluated. Calculated free and bioavailable testosterone were estimated using an algorithm proposed by the International Society for the Study of the Aging Male.
Men diagnosed with MS showed a statistically significant decrease in plasma levels of DHEA in comparison to healthy ones: 11.579 (8.39-15.56) vs 14.014 (9.611-17.125) ng/mL; p = 0.0350, SHBG: 47.46 (35.78-62.83) vs 71.965 (54.45-91.56) nM/L; p<0.0001 and total testosterone: 5.2 (3.8-6.5) vs 6.3 (5.4-8.25) ng/mL; p = 0.0001 (values presented as a median with Q1-Q3).
The results suggest that SHBG is a good early marker for metabolic dysregulation in MS, considering its strength of association and significance is comparable to, or better than, those of MS criteria.
在患有代谢综合征的男性中，伴随的胰岛素抵抗可能导致性激素结合球蛋白（SHBG）血浆水平降低，并引起其雄激素状态的变化。
本研究的目的是评估符合代谢综合征诊断标准的男性与健康男性相比，特定雄激素和SHBG的血浆水平。
该组由65名年龄在40至70岁之间符合国际糖尿病联盟代谢综合征标准的男性和84名对照组成。评估了脱氢表雄酮（DHEA）及其硫酸盐（DHEA-S）、总睾酮和游离睾酮以及SHBG的血清水平。使用国际老年男性研究学会提出的算法估算计算游离睾酮和生物可利用睾酮。
与健康男性相比，被诊断患有代谢综合征的男性血浆中DHEA水平有统计学显著下降：11.579（8.39 - 15.56）ng/mL 对比 14.014（9.611 - 17.125）ng/mL；p = 0.0350，SHBG：47.46（35.78 - 62.83）对比 71.965（54.45 - 91.56）nM/L；p < 0.0001，总睾酮：5.2（3.8 - 6.5）对比 6.3（5.4 - 8.25）ng/mL；p = 0.0001（数值以中位数及Q1 - Q3表示）。
结果表明，考虑到SHBG的关联强度和显著性与代谢综合征标准相当或更好，它是代谢综合征中代谢失调的良好早期标志物。
