Department of Family Medicine, Ajou University School of Medicine, Yeongtong-gu, Suwon, Gyeonggi-do, Republic of Korea.
Maturitas. 2013 Feb;74(2):148-53. doi: 10.1016/j.maturitas.2012.10.016. Epub 2012 Dec 5.
The purpose of this study is to investigate the relationship between sex hormones and metabolic syndrome independent of age and BMI in Korean men.
We conducted a cross-sectional study with data from a health promotion center during the period from March 2007 to February 2010. 2172 Korean men aged 21-79 were enrolled. Total testosterone, sex hormone-binding globulin (SHBG), high density lipoprotein (HDL) cholesterol, triglyceride (TG), and glucose were assessed with overnight fasting serum samples.
Sex hormones were divided into quartiles; odds ratios for metabolic syndrome and each component were analyzed.
Total testosterone showed negative associations with waist circumference (WC), fasting glucose, TG, blood pressure and body mass index (BMI), and a positive relationship with HDL cholesterol (P for trend <0.001, respectively). SHBG was negatively associated with WC, fasting glucose, TG, and BMI, and positively associated with total testosterone and age. Comparing with the highest quartile, odds ratios of lowest quartile of total testosterone and SHBG for metabolic syndrome were 3.01 (95% CI, 2.11-4.28) and 6.34 (95% CI, 2.29-17.58), respectively, after adjusting for age, smoking status, alcohol intake, exercise, and BMI. Total testosterone was significantly associated with each metabolic component and SHBG was associated with glucose and TG after adjustment for age, smoking status, alcohol intake, and BMI. Calculated free testosterone had no significant relationship with metabolic syndrome or its components.
Total testosterone and SHBG are negatively associated with prevalence of metabolic syndrome independent of age and BMI in Korean men.
本研究旨在探讨韩国男性中，性激素与代谢综合征之间的关系，这种关系独立于年龄和 BMI。
我们进行了一项横断面研究，数据来自于 2007 年 3 月至 2010 年 2 月期间的健康促进中心。共纳入 2172 名年龄在 21-79 岁的韩国男性。总睾酮、性激素结合球蛋白（SHBG）、高密度脂蛋白（HDL）胆固醇、甘油三酯（TG）和血糖均通过过夜禁食血清样本进行评估。
性激素分为四组；分析代谢综合征及各组分的比值比。
总睾酮与腰围（WC）、空腹血糖、TG、血压和体重指数（BMI）呈负相关，与 HDL 胆固醇呈正相关（趋势 P<0.001）。SHBG 与 WC、空腹血糖、TG 和 BMI 呈负相关，与总睾酮和年龄呈正相关。与最高四分位组相比，总睾酮和 SHBG 最低四分位组代谢综合征的比值比分别为 3.01（95%CI，2.11-4.28）和 6.34（95%CI，2.29-17.58），经年龄、吸烟状况、饮酒量、运动和 BMI 校正后。总睾酮与每个代谢成分均显著相关，SHBG 与血糖和 TG 相关，经年龄、吸烟状况、饮酒量和 BMI 校正后。计算的游离睾酮与代谢综合征或其组分无显著相关性。
在韩国男性中，总睾酮和 SHBG 与年龄和 BMI 无关，与代谢综合征的患病率呈负相关。
