口服锌治疗普通感冒。
Oral zinc for the common cold.
机构信息
Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, India.
Department of Pediatrics, Post-Graduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
JAMA. 2014 Apr 9;311(14):1440-1. doi: 10.1001/jama.2014.1404.
CLINICAL QUESTION
Is oral zinc associated with a shorter duration, decreased severity, and reduced incidence of the common cold compared with placebo?
BOTTOM LINE
When initiated within 24 hours of symptom onset, oral zinc is associated with a shorter duration of the common cold in healthy people. However, there is no association between oral zinc and symptom severity, and the prevalence of adverse effects with zinc lozenges is high. Given the high heterogeneity of data, these results should be interpreted with caution. Used prophylactically, oral zinc is associated with a reduced cold incidence in children. Prophylactic use has not been studied in adults.
临床问题
与安慰剂相比，口服锌是否与感冒持续时间更短、病情更轻和发病率降低有关？
结论
在症状出现后 24 小时内开始使用时，口服锌可缩短健康人群的普通感冒持续时间。然而，口服锌与症状严重程度之间没有关联，并且锌锭的不良反应发生率很高。鉴于数据的高度异质性，这些结果应谨慎解释。预防性使用口服锌可降低儿童感冒的发病率。预防性使用在成人中尚未进行研究。
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