Lisby S, Ralfkiaer E, Rothlein R, Vejlsgaard G L
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
Br J Dermatol. 1989 Apr;120(4):479-84. doi: 10.1111/j.1365-2133.1989.tb01320.x.
The presence of intercellular adhesion molecule-I (ICAM-I) on keratinocytes of psoriatic skin lesions before and during 8-methoxapsoralen and UVA light (PUVA) treatment was studied. ICAM-I was expressed on the keratinocytes in biopsies of the skin lesions of five patients with psoriasis. The patients who responded to PUVA treatment had a concurrent reduction of ICAM-I expression on the keratinocytes with a reduction of the number of cells in the mononuclear cellular infiltrate and a lessening of the severity of the disease. Patients who went into remission during therapy and then relapsed showed an increase in ICAM-I expression on keratinocytes with an increase in the number of cells in the mononuclear cell infiltrate and an increase in the severity of the disease. HLA-DR expression on keratinocytes was variable during treatment and showed no strong correlation with disease severity.
研究了8-甲氧基补骨脂素和紫外线A光（PUVA）治疗前及治疗期间银屑病皮肤病变角质形成细胞上细胞间黏附分子-I（ICAM-I）的存在情况。五名银屑病患者皮肤病变活检中的角质形成细胞表达了ICAM-I。对PUVA治疗有反应的患者，其角质形成细胞上ICAM-I的表达同时减少，单核细胞浸润中的细胞数量减少，疾病严重程度减轻。治疗期间缓解后又复发的患者，其角质形成细胞上ICAM-I的表达增加，单核细胞浸润中的细胞数量增加，疾病严重程度增加。角质形成细胞上HLA-DR的表达在治疗期间变化不定，与疾病严重程度无强相关性。
