Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
Semin Neurol. 2014 Feb;34(1):14-20. doi: 10.1055/s-0034-1372338. Epub 2014 Apr 8.
Central nervous system (CNS) infection is an important part of systemic human immunodeficiency disease (HIV) infection. It is most often asymptomatic, but can sometimes lead to severe neurologic disease, particularly in advanced stages of immunosuppression. CNS HIV infection usually responds well to antiretroviral treatment, but there are concerns that treatment may not always be fully effective in treating or preventing milder CNS disease and that it, under certain circumstances, might be important to consider antiretroviral drug distribution and effects within the CNS.
中枢神经系统 (CNS) 感染是全身性人类免疫缺陷病毒 (HIV) 感染的重要组成部分。它通常无症状，但有时可导致严重的神经疾病，尤其是在免疫抑制的晚期。中枢神经系统 HIV 感染通常对抗逆转录病毒治疗有良好的反应，但人们担心治疗并不总是能完全有效地治疗或预防较轻度的中枢神经系统疾病，并且在某些情况下，考虑抗逆转录病毒药物在中枢神经系统内的分布和作用可能很重要。
