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冠状动脉内使用替罗非班进行直接血管成形术相关的急性严重血小板减少症。

Acute serious thrombocytopenia associated with intracoronary tirofiban use for primary angioplasty.

作者信息

Yurtdaş Mustafa, Yaylali Yalin Tolga, Aladağ Nesim, Ozdemir Mahmut, Atay Memiş Hilmi

机构信息

Department of Cardiology, Van Region Training and Research Hospital, 65100 Van, Turkey.

Department of Cardiology, Pamukkale University, 20070 Denizli, Turkey.

出版信息

Case Rep Med. 2014;2014:190149. doi: 10.1155/2014/190149. Epub 2014 Mar 10.

DOI:10.1155/2014/190149
PMID:24715904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3970359/
Abstract

Tirofiban, a specific glycoprotein IIb/IIIa inhibitor, may cause extensive thrombocytopenia with an incidence of 0.2% to 0.5%. We report the case of a 50-year-old man who developed thrombocytopenia after tirofiban use (both intracoronary and peripheral) over hours and the successful management of this complication after primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.

摘要

替罗非班是一种特异性糖蛋白IIb/IIIa抑制剂，可能会导致严重血小板减少症，发生率为0.2%至0.5%。我们报告了一例50岁男性患者，其在使用替罗非班（冠状动脉内和外周）数小时后出现血小板减少症，并在对急性ST段抬高型心肌梗死进行直接经皮冠状动脉介入治疗后成功处理了这一并发症。

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本文引用的文献

1
Tirofiban-induced acute profound thrombocytopenia after primary angioplasty.原发性血管成形术后替罗非班诱发的急性严重血小板减少症。
Asian Cardiovasc Thorac Ann. 2013 Feb;21(1):74-6. doi: 10.1177/0218492312445142.
2
2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.2013年美国心脏病学会基金会/美国心脏协会ST段抬高型心肌梗死管理指南：执行摘要：美国心脏病学会基金会/美国心脏协会实践指南工作组报告
Circulation. 2013 Jan 29;127(4):529-55. doi: 10.1161/CIR.0b013e3182742c84. Epub 2012 Dec 17.
3
Severe thrombocytopenia following tirofiban infusion.替罗非班输注后严重血小板减少症。
Indian J Pharmacol. 2011 Nov;43(6):726-8. doi: 10.4103/0253-7613.89837.
4
Profound thrombocytopenia induced by clopidogrel with a prior history of long-term safe administration.氯吡格雷诱导的严重血小板减少症，既往有长期安全用药史。
World J Cardiol. 2010 Jun 26;2(6):160-2. doi: 10.4330/wjc.v2.i6.160.
5
Vanishing platelets: rapid and extreme tirofiban-induced thrombocytopenia after percutaneous coronary intervention for acute myocardial infarction.血小板消失：急性心肌梗死经皮冠状动脉介入治疗后替罗非班引起的快速且极度血小板减少症
Tex Heart Inst J. 2010;37(1):109-12.
6
Thrombocytopenia in adults: A practical approach to evaluation and management.
South Med J. 2006 May;99(5):491-8; quiz 499-500, 533. doi: 10.1097/01.smj.0000209275.75045.d4.
7
Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors.与糖蛋白IIb/IIIa抑制剂使用相关的血小板减少症：国际血栓与止血学会血小板减少症与糖蛋白IIb/IIIa抑制剂工作组立场文件
J Thromb Haemost. 2006 Mar;4(3):678-9. doi: 10.1111/j.1538-7836.2006.01829.x.
8
Frequency and management of thrombocytopenia with the glycoprotein IIb/IIIa receptor antagonists.糖蛋白IIb/IIIa受体拮抗剂所致血小板减少症的发生率及处理
Am J Cardiol. 2006 Feb 1;97(3):426-9. doi: 10.1016/j.amjcard.2005.08.066. Epub 2005 Dec 1.
9
Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.肝素诱导的血小板减少症：识别、治疗与预防：第七届美国胸科医师学会抗栓与溶栓治疗会议
Chest. 2004 Sep;126(3 Suppl):311S-337S. doi: 10.1378/chest.126.3_suppl.311S.
10
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Blood. 2002 Sep 15;100(6):2071-6.