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Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study.氯吡格雷无反应者和有反应者对替卡格雷的反应及转换治疗的效果：RESPOND 研究。
Circulation. 2010 Mar 16;121(10):1188-99. doi: 10.1161/CIRCULATIONAHA.109.919456. Epub 2010 Mar 1.
2
Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: a randomized, controlled study.在急性冠脉综合征患者经皮冠状动脉介入治疗后，除阿司匹林和氯吡格雷外，西洛他唑可改善长期预后：一项随机对照研究。
Am Heart J. 2009 Apr;157(4):733-9. doi: 10.1016/j.ahj.2009.01.006. Epub 2009 Mar 17.
3
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial.普拉格雷与氯吡格雷用于ST段抬高型心肌梗死经皮冠状动脉介入治疗患者的比较（TRITON-TIMI 38）：双盲随机对照试验
Lancet. 2009 Feb 28;373(9665):723-31. doi: 10.1016/S0140-6736(09)60441-4.
4
Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008).噻氯匹定和氯吡格雷相关的血栓性血小板减少性紫癜（TTP）：临床、实验室、流行病学及药物警戒研究结果综述（1989 - 2008年）
Kidney Int Suppl. 2009 Feb(112):S20-4. doi: 10.1038/ki.2008.613.
5
Clopidogrel desensitization: case report and review of published protocols.氯吡格雷脱敏治疗：病例报告及已发表方案综述
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6
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7
Hematologic adverse effects of clopidogrel.氯吡格雷的血液学不良反应。
Am J Ther. 2007 Jan-Feb;14(1):106-12. doi: 10.1097/01.mjt.0000212708.81034.22.
8
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氯吡格雷诱导的严重血小板减少症，既往有长期安全用药史。

Profound thrombocytopenia induced by clopidogrel with a prior history of long-term safe administration.

作者信息

Guo Yuan-Lin, Li Jian-Jun, Yuan Jin-Qing, Qin Xue-Wen, Zheng Xin, Mu Chao-Wei, Hua Yi-Hong

机构信息

Yuan-Lin Guo, Jian-Jun Li, Jin-Qing Yuan, Xue-Wen Qin, Xin Zheng, Chao-Wei Mu, Yi-Hong Hua, Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.

出版信息

World J Cardiol. 2010 Jun 26;2(6):160-2. doi: 10.4330/wjc.v2.i6.160.

DOI:10.4330/wjc.v2.i6.160
PMID:21160734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2999053/
Abstract

Clopidogrel has shown an excellent safety, tolerability and efficacy ever since its marketing. However, here we report a rare case with profound thrombocytopenia following clopidogrel administration previously safely exposed to this same drug. This reminds us that thrombocytopenia might be induced by clopidogrel even with a prior, safe history of long-term administration.

摘要

氯吡格雷自上市以来已显示出出色的安全性、耐受性和疗效。然而，在此我们报告一例罕见病例，该患者在之前曾安全使用过氯吡格雷的情况下，再次服用该药后出现严重血小板减少症。这提醒我们，即使有长期安全用药史，氯吡格雷仍可能诱发血小板减少症。