Sahin Serap Baydur, Yucel Ahmet Fikret, Bedir Recep, Ogullar Sabri, Ayaz Teslime, Algun Ekrem
Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University Medical School, 53020 Rize, Turkey.
Department of Surgery, Recep Tayyip Erdogan University, 53020 Rize, Turkey.
Case Rep Endocrinol. 2014;2014:206890. doi: 10.1155/2014/206890. Epub 2014 Mar 11.
Objective. Oncocytomas of the adrenal cortex are usually benign and nonfunctional. They are rarely seen as the cause of hirsutism. Therefore, we aimed to report a case of adrenocortical oncocytoma presenting with hirsutism. Methods. We report a testosterone- and cortisol-secreting adrenal oncocytoma in a 23-year-old female patient presenting with hirsutism. Results. The patient had the complaint of hirsutism for the last year. Laboratory tests revealed total testosterone level of 4.2 ng/mL, free testosterone of >100 pg/mL, and DHEAS level of 574 µg/dL. There was no suppression in cortisol levels with 2 mg dexamethasone suppression test (5.4 µg/dL). Adrenal MRI revealed a 27 × 25 mm isointense solid mass lesion in the left adrenal gland and the patient underwent laparoscopic left adrenalectomy. Pathological examination confirmed the diagnosis of benign adrenocortical oncoyctoma. Conclusion. This well-characterized case describes a testosterone- and cortisol-secreting adrenocortical oncocytoma as a possible cause of hirsutism. To our knowledge, this is the second report in the literature. Adrenal oncocytomas should always be considered in the differential diagnosis of hirsutism.
目的。肾上腺皮质嗜酸性细胞瘤通常为良性且无功能。它们很少被视为多毛症的病因。因此，我们旨在报告一例表现为多毛症的肾上腺皮质嗜酸性细胞瘤病例。方法。我们报告了一名23岁患有多毛症的女性患者，其肾上腺嗜酸性细胞瘤分泌睾酮和皮质醇。结果。该患者在过去一年一直有毛发过多的主诉。实验室检查显示总睾酮水平为4.2 ng/mL，游离睾酮>100 pg/mL，硫酸脱氢表雄酮水平为574 μg/dL。2 mg地塞米松抑制试验后皮质醇水平无抑制（5.4 μg/dL）。肾上腺MRI显示左肾上腺有一个27×25 mm等密度实性肿块病变，患者接受了腹腔镜左肾上腺切除术。病理检查证实为良性肾上腺皮质嗜酸性细胞瘤。结论。这个特征明确的病例描述了一种分泌睾酮和皮质醇的肾上腺皮质嗜酸性细胞瘤，它可能是多毛症的病因。据我们所知，这是文献中的第二篇报道。在多毛症的鉴别诊断中应始终考虑肾上腺嗜酸性细胞瘤。
