中药药代动力学研究：自动化血液采样系统与液相色谱-质谱联用分析。
Pharmacokinetic Studies of Chinese Medicinal Herbs Using an Automated Blood Sampling System and Liquid Chromatography-mass Spectrometry.
机构信息
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
出版信息
J Tradit Complement Med. 2012 Jan;2(1):33-40. doi: 10.1016/s2225-4110(16)30068-2.
The safety of herbal products is one of the major concerns for the modernization of traditional Chinese medicine, and pharmacokinetic data of medicinal herbs guide us to design the rational use of the herbal formula. This article reviews the advantages of the automated blood sampling (ABS) systems for pharmacokinetic studies. In addition, three commonly used sample preparative methods, protein precipitation, liquid-liquid extraction and solid-phase extraction, are introduced. Furthermore, the definition, causes and evaluation of matrix effects in liquid chromatography-mass spectrometry (LC/MS) analysis are demonstrated. Finally, we present our previous works as practical examples of the application of ABS systems and LC/MS for the pharmacokinetic studies of Chinese medicinal herbs.
草药产品的安全性是中药现代化的主要关注点之一，草药的药代动力学数据指导我们设计草药配方的合理使用。本文综述了自动化血液采样（ABS）系统在药代动力学研究中的优势。此外，还介绍了三种常用的样品制备方法，即蛋白沉淀、液-液萃取和固相萃取。此外，还阐述了液相色谱-质谱（LC/MS）分析中基质效应的定义、原因和评价。最后，我们展示了我们之前的工作，作为 ABS 系统和 LC/MS 在中药药代动力学研究中的应用的实际例子。
Zotero 插件