Department of Biochemical Science & Technology, College of Life Science, National Taiwan University, Taipei, Taiwan, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617, Taiwan.
J Tradit Complement Med. 2012 Jan;2(1):52-60. doi: 10.1016/s2225-4110(16)30071-2.
The protective effect of red mold rice (RMR) against liver injury in rats fed with a Zn-deficient diet for 12 weeks was investigated in this study. Rats were orally administered RMR (151 mg/kg body weight or 755 mg/kg body weight; 1 × dose or 5 × dose, respectively) with or without Zn once a day for 4 consecutive weeks. The severity of liver damage was evaluated by measuring the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in Zn-deficient rats. RMR significantly inhibited the elevation of serum ALT levels by Zn-deficient induction. Hepatic antioxidase activity was also significantly increased in the RMR + Zn group (RZ), thereby suppressing the productions of reactive oxygen species (ROS) and proinflammatory cytokines in the liver of Zn-deficient rats. These findings suggested that RMR exerted hepatoprotective effects against Zn deficiency-induced liver inflammation.
本研究旨在探讨红曲米（RMR）对缺锌饮食喂养 12 周大鼠肝损伤的保护作用。大鼠连续 4 周每天口服 RMR（151mg/kg 体重或 755mg/kg 体重；分别为 1 次剂量和 5 次剂量），同时或不与 Zn 一起给药。通过测量缺锌诱导大鼠血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平来评估肝损伤的严重程度。RMR 显著抑制了由缺锌诱导的血清 ALT 水平升高。RMR+Zn 组（RZ）的肝抗氧化酶活性也显著增加，从而抑制了缺锌大鼠肝脏中活性氧（ROS）和促炎细胞因子的产生。这些发现表明，RMR 对缺锌诱导的肝炎症具有保肝作用。
