Department of Traditional Chinese Medicine, Taipei City Hospital Linsen (Chinese Medicine) Branch, Taipei, Taiwan ; Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.
Bureau of Planning, Department of Health, Executive Yuan, Taipei, Taiwan ; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
J Tradit Complement Med. 2013 Jul;3(3):142-51. doi: 10.4103/2225-4110.114898.
Increased oxidative stress induces inflammation to several tissues/organs leading to cell death and long-term injury. Traditional Chinese Medicine (TCM) with antioxidant, anti-inflammatory, anti-apoptotic, and autophagic regulatory functions has been widely used as preventive or therapeutic strategy in modern medicine. Oxidative stress and inflammation have been widely reported to contribute to cigarette smoke-induced lung inflammation, hepatotoxicity, or sympathetic activation-induced liver inflammation, lipopolysaccharide-induced renal inflammation, and substance P-mediated neurogenic hyperactive bladder based on clinical findings. In this review, we introduce several evidences for TCM treatment including Monascus adlay (MA) produced by inoculating adlay (Cois lachrymal-jobi L. var. ma-yuen Stapf) with Monascus purpureus on lung injury, Amla (Emblica officinalis Gaertn. of Euphorbiaceae family) on hepatotoxin-induced liver inflammation, Virgate Wormwood Decoction (Yīn Chén Hāo tāng) and its active component genipin on sympathetic activation-induced liver inflammation, and green tea extract and its active components, catechins, or a modified TCM formula Five Stranguries Powder (Wǔ Lén Sǎn) plus Crataegi Fructus (Shān Zhā) on hyperactive bladder. The pathophysiologic and molecular mechanisms of TCM on ameliorating inflammatory diseases are discussed in the review.
氧化应激会引发多个组织/器官的炎症，导致细胞死亡和长期损伤。具有抗氧化、抗炎、抗细胞凋亡和自噬调节功能的中药在现代医学中被广泛用作预防或治疗策略。基于临床发现，氧化应激和炎症被广泛报道与香烟烟雾引起的肺炎症、肝毒性或交感神经激活引起的肝炎症、脂多糖引起的肾炎症以及物质 P 介导的神经源性过度活跃的膀胱有关。在这篇综述中，我们介绍了几种中药治疗的证据，包括红曲米（Monascus adlay，MA）对肺损伤的治疗作用、余甘子（Amla，Emblica officinalis Gaertn.）对肝毒素引起的肝炎症的治疗作用、茵陈蒿汤（Virgate Wormwood Decoction，Yīn Chén Hāo tāng）及其活性成分栀子苷（genipin）对交感神经激活引起的肝炎症的治疗作用，以及绿茶提取物及其活性成分儿茶素或改良中药配方五淋散（Wǔ Lén Sǎn）加山楂（Crataegi Fructus，Shān Zhā）对过度活跃的膀胱的治疗作用。本文讨论了中药改善炎症性疾病的病理生理和分子机制。
