Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
J Dig Dis. 2014 Jul;15(7):345-51. doi: 10.1111/1751-2980.12152.
Patency capsule (PC) is a tool to screen the patency of the gastrointestinal (GI) tract. Capsule endoscopy can be performed after the patency is confirmed by the patency capsule. We aimed to estimate the diagnostic value of PC based on the existing trials.
We searched PubMed, CENTRAL and EMBASE for studies that included patients with suspected small bowel stricture who were evaluated by both PC and a reference standard (following capsule endoscopy and/or surgical pathology and/or endoscopic findings) and who were eligible for inclusion. The quality of the eligible studies was assessed using the Quality Assessment for Diagnostic Accuracy Studies-2 criteria. Sensitivity, specificity, likelihood ratios and the area under the receiver operating characteristic curve (AUROC) were calculated.
Five studies including 203 patients fulfilled the eligibility criteria. The pooled data showed a PC sensitivity of 97% (95% CI 93-99%) and a specificity of 83% (95% CI 65-94%). The AUROC was 0.9557.
PC may be of diagnostic value in confirming the patency of the GI tract before capsule endoscopy. The routine use of PC might eliminate the contraindication of capsule endoscopy in many cases of intestinal obstruction.
通畅胶囊（PC）是一种用于筛查胃肠道（GI）通畅性的工具。在通畅性得到确认后，可以进行胶囊内镜检查。我们旨在根据现有试验评估 PC 的诊断价值。
我们检索了 PubMed、CENTRAL 和 EMBASE 中包含疑似小肠狭窄患者的研究，这些患者均通过 PC 和参考标准（随后进行胶囊内镜检查和/或手术病理和/或内镜检查）进行了评估，并且符合纳入标准。使用诊断准确性研究质量评估工具-2 标准评估合格研究的质量。计算了敏感性、特异性、似然比和受试者工作特征曲线下的面积（AUROC）。
五项研究共纳入 203 名患者，符合纳入标准。汇总数据显示 PC 的敏感性为 97%（95%CI 93-99%），特异性为 83%（95%CI 65-94%）。AUROC 为 0.9557。
PC 可能在确认胶囊内镜检查前 GI 道通畅性方面具有诊断价值。在许多肠梗阻病例中，常规使用 PC 可能会消除胶囊内镜检查的禁忌证。
