Tehrani F R, Mansournia M A, Solaymani-Dodaran M, Azizi F
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Climacteric. 2014 Oct;17(5):591-7. doi: 10.3109/13697137.2014.912262. Epub 2014 Jul 9.
Despite the wide use of anti-Müllerian hormone (AMH) measurement as a clinical marker for assessment of ovarian reserve, a population-based estimate for its reference values is not available. In this study, we have estimated age-specific AMH levels in a large sample of fertile women directly selected from a general population cohort.
All women who were naturally fertile and aged 18-50 years with regular menstrual cycles were selected from the Tehran Lipid and Glucose Study cohort and their blood levels of AMH were measured. Centiles for AMH distribution were estimated according to the exponential-normal 3-parameter model. We repeated the analysis after including a subgroup of women aged 40-50 years who met all the eligibility criteria except having entered natural menopause after age 40 years (n = 141).
A total of 1015 women entered the study. The mean age was 36.7 years (standard deviation 7.5 years) and the mean body mass index was 27.0 kg/m(2) (standard deviation 4.6 kg/m(2)). A non-linear decline of serum AMH concentration with age was observed. Age-specific AMH levels for the 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles were calculated.
were reproduced after inclusion of 141 women aged 40-50 years who met all the eligibility criteria except having entered natural menopause after 40 years.
In this study, we have presented a nomogram of age-specific estimates of anti-Müllerian hormone in a large sample of naturally fertile women within the general population. This could help clinicians in more accurate individual interpretation of serum AMH levels in healthy women.
尽管抗苗勒管激素（AMH）检测作为评估卵巢储备功能的临床指标已被广泛应用，但目前尚无基于人群的AMH参考值估计。在本研究中，我们直接从一般人群队列中选取了大量有生育能力的女性样本，对特定年龄的AMH水平进行了估计。
从德黑兰血脂与血糖研究队列中选取所有自然生育、年龄在18 - 50岁且月经周期规律的女性，并检测其血液中的AMH水平。根据指数-正态三参数模型估计AMH分布的百分位数。在纳入一组年龄在40 - 50岁、除40岁后进入自然绝经外符合所有入选标准的女性亚组（n = 141）后，我们重复了分析。
共有1015名女性进入研究。平均年龄为36.7岁（标准差7.5岁），平均体重指数为27.0 kg/m²（标准差4.6 kg/m²）。观察到血清AMH浓度随年龄呈非线性下降，并计算了第5、10、25、50、75、90和95百分位数的特定年龄AMH水平。在纳入141名年龄在40 - 50岁、除40岁后进入自然绝经外符合所有入选标准的女性后，结果得以重现。
在本研究中，我们给出了一般人群中大量自然生育女性抗苗勒管激素特定年龄估计的列线图。这有助于临床医生更准确地对健康女性的血清AMH水平进行个体解读。
