Narayanan R B, Natarajan M, Katoch K, Sengupta U
Central Jalma Institute for Leprosy (ICMR), Agra, India.
Int Arch Allergy Appl Immunol. 1989;89(1):38-42. doi: 10.1159/000234920.
A comparison was made on the characteristics of the infiltrates, the number and distribution of CD1-positive epidermal Langerhans cells (LC) at the sites of skin reaction induced by autologous peripheral-blood-derived mononuclear cells (PBMC) in leprosy patients. Clinically and histologically, the skin reaction was well expressed in tuberculoid patients as compared to lepromatous patients, erythema nodosum leprosum (ENL) patients and contacts. The quantum of lymphocytes in the infiltrates was maximal in the tuberculoid patients and it was minimal in lepromatous and ENL patients. The number and distribution of LC in the tuberculoid patients was significantly higher in the PBMC-inoculated sites as compared to control sites over 24 h. In contrast, no difference in the number and distribution of LC was noticed in the lepromatous and ENL patients. These observations indicate that the lymphocytes of tuberculoid patients in contrast to lepromatous leprosy patients are capable of sustenance in the local micro-environments of the skin and an effective interaction may be possible between LC and PBMC.
对麻风患者自体外周血来源的单个核细胞（PBMC）诱导的皮肤反应部位的浸润特征、CD1阳性表皮朗格汉斯细胞（LC）的数量和分布进行了比较。临床和组织学观察发现，与瘤型麻风患者、结节性红斑型麻风（ENL）患者及其接触者相比，结核样型患者的皮肤反应表现良好。浸润物中淋巴细胞数量在结核样型患者中最多，在瘤型和ENL患者中最少。与对照部位相比，结核样型患者在PBMC接种部位24小时内LC的数量和分布显著更高。相反，瘤型和ENL患者的LC数量和分布没有差异。这些观察结果表明，与瘤型麻风患者相比，结核样型患者的淋巴细胞能够在皮肤局部微环境中维持存活，并且LC与PBMC之间可能存在有效的相互作用。
