Owlia Mohammad Bagher, Distler Oliver, Foratyazdi Mohammad, Akhtari Mojtaba
Department of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Medicine, University Hospital Zurich, Zurich, Switzerland.
J Coll Physicians Surg Pak. 2014 Mar;24 Suppl 1:S29-31.
Some connective tissue diseases are associated with an increased risk of developing neoplastic disorders. Association of rheumatoid arthritis and systemic lupus erythematosus with lymphoma, and of dermatomyositis with different malignancies including ovarian and lung cancer has been reported in the literature. Here, we describe a 58 years old man with systemic sclerosis (SSc) for 15 years who developed severe lumbar pain when he was admitted for intravenous infusion of prostaglandin E1 for his fingertip ulcers. He was found to have abnormal skeletal imaging. Laboratory tests including bone marrow aspiration and biopsy determined multiple myeloma causing extensive bony infiltration. The patient expired after two cycles of VAD and Bortezomide chemotherapy.
一些结缔组织病与发生肿瘤性疾病的风险增加有关。类风湿关节炎和系统性红斑狼疮与淋巴瘤的关联，以及皮肌炎与包括卵巢癌和肺癌在内的不同恶性肿瘤的关联，在文献中已有报道。在此，我们描述一名58岁男性，患有系统性硬化症（SSc）15年，因指尖溃疡入院接受前列腺素E1静脉输注时出现严重腰痛。他的骨骼影像学检查显示异常。包括骨髓穿刺和活检在内的实验室检查确诊为多发性骨髓瘤，导致广泛的骨质浸润。该患者在接受两个周期的VAD和硼替佐米化疗后死亡。
