Pujol J A, Bueno M, Fuertes M A, Gimenez H, Carapeto F J
Department of Dermatology, Hospital Clinico Universitario, Faculty of Medicine, Zaragoza, Spain.
Clin Exp Dermatol. 1995 Mar;20(2):149-52. doi: 10.1111/j.1365-2230.1995.tb02721.x.
The presence of a monoclonal gammopathy in patients with chronic scleredema is a recently described, unusual association of unknown significance. There have been very occasional reports of multiple myeloma in such patients. We now report a patient with long-standing scleredema who developed an IgA-kappa multiple myeloma. Once chemotherapy for the myeloproliferative disorder was instituted, scleredema improved significantly, suggesting a pathogenetic link between the two conditions.
慢性硬化性水肿患者中出现单克隆丙种球蛋白病是最近描述的一种意义不明的罕见关联。此类患者中曾有极个别关于多发性骨髓瘤的报道。我们现在报告一例长期患有硬化性水肿的患者，其发展为IgA-κ型多发性骨髓瘤。一旦开始针对骨髓增殖性疾病进行化疗，硬化性水肿明显改善，提示这两种病症之间存在发病机制上的联系。
