Mirhafez S R, Ebrahimi M, Saberi Karimian M, Avan A, Tayefi M, Heidari-Bakavoli A, Parizadeh M R, Moohebati M, Azarpazhooh M R, Esmaily H, Nematy M, Safarian M, Ferns G A, Ghayour-Mobarhan M
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Eur J Clin Nutr. 2016 Nov;70(11):1298-1304. doi: 10.1038/ejcn.2016.111. Epub 2016 Jul 27.
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is characterized by abdominal obesity, dyslipidemia, hypertension and glucose intolerance, and is associated with an increased risk of developing cardiovascular disease (CVD), diabetes mellitus and related diseases. Circulating levels of inflammatory markers such as C-reactive-protein (CRP) have reported to be associated with CVD. Against this background, the prevalence of MetS is increasing globally, and thus predictive biomarkers are required for identification of MetS patients at an increased risk. Here we explored the value of CRP as a biomarker in 7284 subjects and also investigated which features of MetS have the greatest association with the hs-CRP level.
SUBJECTS/METHODS: The subjects were recruited from the Mashhad stroke and heart atherosclerotic disorder study. Anthropometric factors and biochemical parameters (for example, high-sensitivity CRP (hs-CRP), high-density lipoprotein/low-density lipoprotein, triglycerides (TGs) and fasting blood glucose (FBG)) were determined. Univariate and multivariate analyses were conducted to evaluate the association of hs-CRP and MetS.
Our results illustrated that the concentration of serum hs-CRP increased progressively with the number of MetS components, and subjects who fulfilled the criteria of MetS for waist circumference, TGs, blood pressure and FBG were found to have hs-CRP of 0.53, 0.38, 0.34 and 0.71 mg/l, respectively, higher than matched-subjects. Importantly, FBG had the greatest association with hs-CRP concentration.
Our data demonstrate the significant association between MetS components with hs-CRP, indicating that this association was cumulative by increasing the number of the defining features of MetS, supporting further studies to explore the value of emerging marker as a novel method for detecting individuals at high risk of developing MetS.
背景/目的：代谢综合征（MetS）的特征为腹型肥胖、血脂异常、高血压和糖耐量异常，与心血管疾病（CVD）、糖尿病及相关疾病的发病风险增加有关。据报道，循环炎症标志物如C反应蛋白（CRP）的水平与心血管疾病有关。在此背景下，全球范围内代谢综合征的患病率正在上升，因此需要预测性生物标志物来识别患病风险增加的代谢综合征患者。我们在此研究了7284名受试者中CRP作为生物标志物的价值，并调查了代谢综合征的哪些特征与超敏CRP（hs-CRP）水平关联最大。
受试者/方法：受试者来自马什哈德中风和心脏动脉粥样硬化疾病研究。测定人体测量因素和生化参数（例如，高敏CRP（hs-CRP）、高密度脂蛋白/低密度脂蛋白、甘油三酯（TGs）和空腹血糖（FBG））。进行单变量和多变量分析以评估hs-CRP与代谢综合征的关联。
我们的结果表明，血清hs-CRP浓度随着代谢综合征组分数量的增加而逐渐升高，并且发现符合腰围、TGs、血压和FBG代谢综合征标准的受试者的hs-CRP分别比匹配受试者高0.53、0.38、0.34和0.71mg/l。重要的是，FBG与hs-CRP浓度的关联最大。
我们的数据表明代谢综合征组分与hs-CRP之间存在显著关联，这表明这种关联随着代谢综合征定义特征数量的增加而累积，支持进一步研究以探索新兴标志物作为检测代谢综合征高风险个体的新方法的价值。
