Ugarte-Gil M F, Gamboa-Cárdenas R V, Zevallos F, Medina M, Cucho-Venegas J M, Perich-Campos R A, Alfaro-Lozano J L, Rodriguez-Bellido Z, Alarcón G S, Pastor-Asurza C A
Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú Universidad Científica del Sur, Perú
Servicio de Reumatología, Hospital Nacional Guillermo Almenara Irigoyen, Perú
Lupus. 2014 Sep;23(10):969-74. doi: 10.1177/0961203314531083. Epub 2014 Apr 9.
to determine whether prolactin levels are independently associated with disease damage in systemic lupus erythematosus (SLE) patients.
these cross-sectional analyses were conducted in SLE patient members of the Almenara Lupus Cohort who were seen between January 2012 and June 2013. Disease damage was ascertained with the System Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI). Prolactin was measured in ng/ml. The association between prolactin levels and the SDI (total and its domains) was evaluated using Spearman's correlation. Subsequently, adjusted Poisson regression models were performed to evaluate these associations.
160 patients were included. 147 (91.9%) were female; their median age at diagnosis was 33.4 (interquartile range (IQR): 26.0-44.3) years; their disease duration was 5.5 (IQR: 2.6-9.7) years. The median prolactin value was 16.8 (IQR: 11.8-24.5) ng/ml. After adjusting for confounders in the Poisson regression model the estimated rate ratios (RR) and 95% confidence interval (CI) for each 10 ng/ml increment of prolactin were 1.13 (95% CI 1.60-1.20, p<0.001) for the total SDI score, 1.15 (1.03-1.28, p=0.003) for the renal domain and 1.41 (1.11-1.79, p=0.003) for the cardiac/peripheral vascular domains.
there was a positive association between prolactin levels and the SDI (overall and its renal and cardiac/peripheral vascular domains), independently of other well-known risk factors.
确定催乳素水平是否与系统性红斑狼疮（SLE）患者的疾病损害独立相关。
对2012年1月至2013年6月期间就诊的阿尔梅纳拉狼疮队列中的SLE患者进行了这些横断面分析。采用国际狼疮协作临床中心/美国风湿病学会（SLICC/ACR）损伤指数（SDI）确定疾病损害情况。催乳素的测量单位为ng/ml。使用Spearman相关性评估催乳素水平与SDI（总分及其各领域）之间的关联。随后，进行调整后的泊松回归模型以评估这些关联。
纳入160例患者。147例（91.9%）为女性；诊断时的中位年龄为33.4岁（四分位间距（IQR）：26.0 - 44.3岁）；病程为5.5年（IQR：2.6 - 9.7年）。催乳素的中位值为16.8 ng/ml（IQR：11.8 - 24.5 ng/ml）。在泊松回归模型中对混杂因素进行调整后，催乳素每增加10 ng/ml，总SDI评分的估计率比（RR）和95%置信区间（CI）为1.13（95%CI 1.60 - 1.20，p<0.001），肾脏领域为1.15（1.03 - 1.28，p = 0.003），心脏/外周血管领域为1.41（1.11 - 1.79，p = 0.003）。
催乳素水平与SDI（总体及其肾脏和心脏/外周血管领域）之间存在正相关，且独立于其他已知风险因素。
