Samy Nevien, Fadel Maha
J Drugs Dermatol. 2014 Apr;13(4):436-42.
Blond and white hair removal by laser is a complicated task with weak satisfactory results due to the deficiency in laser-absorbing chromophore.
To investigate if repetitive sessions of photodynamic therapy (PDT) using external application of liposomal Rose bengal (RB) photosensitizer followed by intense pulsed light (IPL) exposure enables removal of gray and white hair.
Rose bengal loaded in liposomes (LRB) was constructed, prepared in hydrogel, and was studied for some pharmaceutical properties. Penetration and selective hair follicle damage in mice skin were studied. Topical gel containing LRB was used for treating fifteen adult females who were complaining of facial white terminal hair. Unwanted facial hair was treated for three sessions at intervals of 4-6 weeks using intense pulsed light (IPL). At each session, the treatment area was pre-treated with topical LRB gel, while a control group of another 15 patients applied placebo gel before IPL treatment. Evaluations included hair regrowth, which was measured 4 weeks after each treatment session and at 6 months follow-up by counting the number of terminal hair compared with baseline pretreatment values. Treatment outcomes and complications if any were also reported.
Average hair regrowth in the LRB group was 56% after 3 treatment cycles. After six-months follow up, average terminal hair count compared with baseline pretreatment showed 40% reduction and no recorded side effects. A significant difference (P<0.05) was seen compared with the control group; the clinical results were promising.
Photodynamic hair removal using rose bengal-encapsulated liposomal gel in combination with IPL treatment showed significant efficacy in the treatment of white hair compared with a control group.
由于激光吸收发色团的缺乏，通过激光去除金色和白色毛发是一项复杂的任务，效果不尽人意。
研究使用外用脂质体孟加拉玫瑰红（RB）光敏剂进行重复光动力疗法（PDT），随后进行强脉冲光（IPL）照射是否能够去除灰色和白色毛发。
构建负载孟加拉玫瑰红的脂质体（LRB），制备成水凝胶，并研究其一些药学性质。研究了小鼠皮肤中的渗透和选择性毛囊损伤。使用含有LRB的外用凝胶治疗15名抱怨面部有白色终毛的成年女性。使用强脉冲光（IPL），每隔4 - 6周对不需要的面部毛发进行三个疗程的治疗。在每个疗程中，治疗区域先用外用LRB凝胶预处理，而另一组15名患者的对照组在IPL治疗前使用安慰剂凝胶。评估包括毛发生长情况，在每次治疗疗程后4周以及6个月随访时，通过计算终毛数量并与基线预处理值进行比较来测量。还报告了治疗结果和并发症（如有）。
LRB组在3个治疗周期后平均毛发生长为56%。六个月随访后，与基线预处理相比，平均终毛数量减少了40%，且未记录到副作用。与对照组相比有显著差异（P<0.05）；临床结果很有前景。
与对照组相比，使用包裹孟加拉玫瑰红的脂质体凝胶联合IPL治疗进行光动力脱毛在治疗白发方面显示出显著疗效。
