在甲型血友病的高暴露未感染个体中，HLA I类基因和杀伤细胞免疫球蛋白样受体基因不能预防1型HIV感染。
HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A.
作者信息
Vince Nicolas, Bashirova Arman A, Lied Alexandra, Gao Xiaojiang, Dorrell Lucy, McLaren Paul J, Fellay Jacques, Carrington Mary
机构信息
Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Maryland Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.
出版信息
J Infect Dis. 2014 Oct 1;210(7):1047-51. doi: 10.1093/infdis/jiu214. Epub 2014 Apr 8.
Abstract
A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.
摘要
最近一项全基因组关联研究（GWAS）纳入了暴露于1型人类免疫缺陷病毒（HIV-1）但未感染的甲型血友病患者，研究结果显示，除CCR5-Δ32纯合子外，未发现与HIV-1感染抗性相关的基因变异。由于标准GWAS技术对HLA I类和KIR基因变异的研究不够深入，我们利用来自普通人群的对照，在同一血友病队列中测试了这两个基因座是否参与了对HIV-1感染的保护作用。我们的数据表明，HLA I类等位基因、KIR基因的有无以及HLA/KIR基因型的功能相关组合均不参与对经肠道外传播的HIV-1感染的抗性。
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