Unidad de Inmunogenética, Genética, Departamento de Biología Experimental, Universidad de Jaén.
Servicio de Enfermedades Infecciosas y Microbiología Clínica, Complejo Hospitalario de Jaén.
J Infect Dis. 2024 Nov 15;230(5):e1077-e1081. doi: 10.1093/infdis/jiae436.
Human leukocyte antigen (HLA) class I/killer cell immunoglobulin-like receptor (KIR) genotypes influence human immunodeficiency virus type 1 (HIV-1) disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral versus sexual-may influence this association. We conducted a genome-wide association study in a population of people with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.
人类白细胞抗原（HLA）I 类/杀伤细胞免疫球蛋白样受体（KIR）基因型影响人类免疫缺陷病毒 1 型（HIV-1）疾病进展和病毒载量，但它们在原发感染中的作用尚不确定。先前研究的结果不一致表明，接种剂量和传播途径- 性传播与注射传播-可能影响这种关联。我们在一组通过性途径感染 HIV-1 的 HIV-1 感染者和 HIV-1 暴露阴性个体中进行了全基因组关联研究。我们的数据不支持 HLA/KIR 系统在易感性方面的任何作用 性传播的 HIV-1 感染。HIV-1 病毒载量和疾病进展的遗传基础与 HIV 抵抗的遗传基础不同，这是一个值得探讨的悖论。
