School of Biotechnology and Biomolecular Sciences; University of New South Wales; Sydney, NSW Australia.
School of Molecular Bioscience; University of Sydney; Sydney, NSW Australia.
Adipocyte. 2014 Apr 1;3(2):88-96. doi: 10.4161/adip.27552. Epub 2014 Jan 8.
Obesity is a major public health concern and a strong risk factor for insulin resistance, type 2 diabetes mellitus (T2DM), and cardiovascular disease. The last two decades have seen a reconsideration of the role of white adipose tissue (WAT) in whole body metabolism and insulin action. Adipose tissue-derived cytokines and hormones, or adipokines, are likely mediators of metabolic function and dysfunction. While several adipokines have been associated with obese and insulin-resistant phenotypes, a select group has been linked with insulin sensitivity, namely leptin, adiponectin, and more recently, adipolin. What is known about these insulin-sensitizing molecules and their effects in healthy and insulin resistant states is the subject of this review. There remains a significant amount of research to do to fully elucidate the mechanisms of action of these adipokines for development of therapeutics in metabolic disease.
肥胖是一个主要的公共卫生关注点，也是胰岛素抵抗、2 型糖尿病（T2DM）和心血管疾病的一个强危险因素。在过去的二十年中，人们重新审视了白色脂肪组织（WAT）在全身代谢和胰岛素作用中的作用。脂肪组织来源的细胞因子和激素，或脂联素，可能是代谢功能和功能障碍的介质。虽然有几种脂联素与肥胖和胰岛素抵抗表型有关，但有一组脂联素与胰岛素敏感性有关，即瘦素、脂联素，最近还有脂联素。关于这些胰岛素增敏分子及其在健康和胰岛素抵抗状态下的作用的了解是本综述的主题。为了充分阐明这些脂联素在代谢性疾病治疗中的作用机制，还有大量的研究工作要做。
