牙周病中RANKL的表达：RANKL来自何处？
RANKL expression in periodontal disease: where does RANKL come from?
作者信息
Chen Bin, Wu Wenlei, Sun Weibin, Zhang Qian, Yan Fuhua, Xiao Yin
机构信息
Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China.
Bone Research Laboratory, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, Qld 4059, Australia.
出版信息
Biomed Res Int. 2014;2014:731039. doi: 10.1155/2014/731039. Epub 2014 Feb 27.
Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.
牙周炎是一种以牙周袋形成和牙槽骨吸收为特征的炎症性疾病。牙周骨吸收由破骨细胞和核因子κB受体活化因子配体（RANKL）诱导，RANKL是破骨细胞发育和破骨细胞功能的重要且核心的调节因子。因此，RANKL在牙周骨吸收中起关键作用。在本综述中，我们总结了牙周疾病中RANKL的来源，并探讨了哪些因素可能调节该疾病中RANKL的表达。
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