Departamento de Microbiología y Parasitología, Facultad de Medicina, Col. Universidad Nacional Autónoma de México, Av. Universidad 3000, CP 04510, Mexico City, Mexico.
Posgrado en Ciencias Biológicas, Unidad de Posgrado, Ciudad Universitaria, Edificio D, 1° Piso, Mexico City, Mexico.
Odontology. 2023 Oct;111(4):778-792. doi: 10.1007/s10266-023-00798-w. Epub 2023 Mar 10.
Porphyromonas gingivalis is a keystone pathogen associated with periodontitis development, a chronic inflammatory pathology characterized by the destruction of the supporting teeth structure. Macrophages are recruited cells in the inflammatory infiltrate from patients with periodontitis. They are activated by the P. gingivalis virulence factors arsenal, promoting an inflammatory microenvironment characterized by cytokine production (TNF-α, IL-1β, IL-6), prostaglandins, and metalloproteinases (MMPs) that foster the tissular destruction characteristic of periodontitis. Furthermore, P. gingivalis suppresses the generation of nitric oxide, a potent antimicrobial molecule, through its degradation, and incorporating its byproducts as a source of energy. Oral antimicrobial peptides can contribute to controlling the disease due to their antimicrobial and immunoregulatory activity, which allows them to maintain homeostasis in the oral cavity. This study aimed to analyze the immunopathological role of macrophages activated by P. gingivalis in periodontitis and suggested using antimicrobial peptides as therapeutic agents to treat the disease.
牙龈卟啉单胞菌是一种与牙周炎发展相关的关键病原体，牙周炎是一种慢性炎症性病理，其特征是牙齿支撑结构的破坏。巨噬细胞是牙周炎患者炎症浸润中的募集细胞。它们被牙龈卟啉单胞菌的毒力因子库激活，促进细胞因子（TNF-α、IL-1β、IL-6）、前列腺素和金属蛋白酶（MMPs）产生的炎症微环境，这些物质促进了牙周炎的组织破坏特征。此外，牙龈卟啉单胞菌通过降解来抑制一氧化氮的产生，一氧化氮是一种有效的抗菌分子，并将其副产物作为能量来源。口腔抗菌肽由于其抗菌和免疫调节活性，可以有助于控制疾病，使口腔保持内环境稳定。本研究旨在分析被牙龈卟啉单胞菌激活的巨噬细胞在牙周炎中的免疫病理作用，并提出使用抗菌肽作为治疗该疾病的治疗剂。
