Skrypnik Damian, Bogdański Paweł, Madry Edyta, Pupek-Musialik Danuta, Walkowiak Jarosław
Pol Merkur Lekarski. 2014 Feb;36(212):117-21.
Endothelium plays an important role in regulation of the activity of inflammation and oxidative stress. Numerous studies have shown that physical training affects endothelial function. It is proven that regular physical activity reduces the seventy of inflammation and the risk of cardiovascular events. Changes observed in effect of physical activity include increase in production of nitric oxide (NO), a decrease of plaque volume, a decrease in vascular wall viscosity and an increase in diastolic coronary perfusion. It has been shown that exercise reduces cardiovascular risk in subjects with diabetes, metabolic syndrome, coronary heart disease and hypertension, as well as in healthy people. In above populations the benefits result from improved endothelial function. It has been proven that regular physical activity improves enzymatic antioxidant systems and the immune response. It is a result of the stimulating effect of muscle tissue micro-injuries and recruitment of various cell types of the inflammatory response and their migration deeper into the tissues. The biggest changes in the immune response are observed in prolonged aerobic exercise. Physical activity has a significant impact on endothelial function, intensity of inflammatory processes and exponents of oxidative stress. There is a need for further researches, in particular in order to determine the optimal model of training.
内皮在炎症和氧化应激活动的调节中发挥着重要作用。众多研究表明，体育锻炼会影响内皮功能。事实证明，规律的体育活动可降低炎症程度以及心血管事件的风险。体育活动所观察到的变化包括一氧化氮（NO）生成增加、斑块体积减小、血管壁黏度降低以及舒张期冠状动脉灌注增加。研究表明，运动可降低糖尿病、代谢综合征、冠心病和高血压患者以及健康人群的心血管风险。在上述人群中，益处源于内皮功能的改善。事实证明，规律的体育活动可改善酶抗氧化系统和免疫反应。这是肌肉组织微损伤的刺激作用以及炎症反应中各种细胞类型的募集及其向组织深处迁移的结果。在长时间有氧运动中可观察到免疫反应的最大变化。体育活动对内皮功能、炎症过程强度和氧化应激指标有重大影响。有必要进行进一步研究，特别是为了确定最佳训练模式。
