脑心肌炎病毒起始和终止翻译区域同义密码子使用的特征

The characteristics of synonymous codon usage in the initial and terminal translation regions of encephalomyocarditis virus.

作者信息

Ma X-X, Feng Y-P, Liu J-L, Zhao Y-Q, Chen L, Guo P-H, Guo J-Z, Ma Z-R

出版信息

Acta Virol. 2014;58(1):86-91. doi: 10.4149/av_2014_01_86.

DOI:10.4149/av_2014_01_86

PMID:24720745

Abstract

The synonymous codon usage patterns in the initial and terminal translation regions (ITR, TTR) of the whole coding sequence of encephalomyocarditis virus (EMCV) were analyzed in relation to those in its natural hosts using the sequences accessible in databases. In general, some low-usage host codons were found over-represented in the ITR and TTR of the virus, while some high-usage host codons were found under-represented in the two viral regions. These relationships are thought to participate in the regulation of the speed of translation of viral proteins and in the suppression of ribosomal traffic jams, both aiming at the increase of virus yields.

摘要

利用数据库中可获取的序列，分析了脑心肌炎病毒（EMCV）全编码序列的起始和终止翻译区域（ITR、TTR）中的同义密码子使用模式，并将其与该病毒天然宿主中的同义密码子使用模式进行了比较。总体而言，发现一些宿主中使用频率较低的密码子在病毒的ITR和TTR中过度出现，而一些宿主中使用频率较高的密码子在这两个病毒区域中出现频率较低。这些关系被认为参与了病毒蛋白翻译速度的调节以及核糖体交通堵塞的抑制，两者均旨在提高病毒产量。